摘要： Introduction: Studies report varying effects of sex and age on survival and neurological outcome in patients admitted to hospital following an out-of-hospital cardiac arrest (OHCA). Objectives/Aims: To determine if patient sex or age is associated with survival or good neurological outcome at hospital discharge in adult OHCAs of medical aetiology admitted to tertiary intensive care units in Western Australia. Methods: We conducted a retrospective medical record review of OHCA patients >18 years attended by St John WA in metropolitan Perth and admitted to four tertiary intensive care units, January 2012 to December 2017. Adjusted multivariable logistic regression analysis was used to identify patient and pre-hospital factors associated with survival or good neurological outcome (Cerebral Performance Category Scale [CPC]<3) at hospital discharge. Results: Of 8016 OHCAs of medical aetiology attended by St John WA, 3997/8016 (49.9%) had resuscitation attempted with 502/3997 (12.6%) admitted to intensive care. Of these, 144 (29%) were female, mean age was 58.8 years, 313 (62.4%) had an initial shockable rhythm, 284 (56.6%) were witnessed, 349 (69.5%) received bystander cardiopulmonary resuscitation, 79 (15.7%) were admitted to hospital with ongoing cardiopulmonary resuscitation. Of the 237/502 (47.2%) hospital survivors, 215/237 (90.7%) had a CPC<3. Differences in outcomes between the sexes were not statistically significant after multivariable adjustment (survival to hospital discharge p=0.46; CPC<3 p=0.06). Compared with patients 18-44 years, only those >65 years had significantly lower survival (odds ratio 0.32; 95% confidence interval 0.17-0.57); however CPC<3 was not significantly different between age groups. Patients aged >65 years were also less likely to survive (odds ratio 0.18; 0.08-0.39) when analysis was restricted to those with initial shockable rhythm. Conclusions: Older patients (>65 years) were less likely to survive to hospital discharge aft

摘要： 《临床神经病学杂志》系国家级神经病学专业性学术刊物,由南京医科大学附属脑科医院主办。刊登内容以临床神经病学为主,兼及有关边缘学科。读者对象以从事临床神经病学专业的高、中级人员为主,也可供内科、儿科、眼科、五官科医师参阅。本刊的办刊宗旨是:面向临床,面向基层,注重实用,鼎力于提高我国临床神经科医师的专业理论及诊疗水平。

摘要： 《临床神经病学杂志》系国家级神经病学专业性学术刊物,由南京医科大学附属脑科医院主办,刊登内容以临床神经病学为主,兼及有关边缘学科。读者对象以从事临床神经病学专业的高、中级人员为主,也可供内科、儿科、眼科、五官科医师参阅。本刊的办刊宗旨是:面向临床,面向基层,注重实用,鼎力于提高我国临床神经科医师的专业理论及诊疗水平。一、本刊设有专家论坛、述评、论著、学术交流、专题笔谈、综述、讲座、临床病理(例)讨论、教学园地、问题解答、临床研究、病例报告、误诊误治、技术改进等栏目,接受全国各地来稿。

关键词： Amitriptyline   clonazepam   neurology   off-label  

摘要： Off-label drug use refers to any use of an approved or cleared drug that is not included in that product's approved labeling or cleared indications for use. It may be in terms of indication, age group, dosage, or route of administration. Off-label drug prescriptions are common neurology practice. Aim: The aim of the study is to evaluate the prevalence pattern of off-label drug use in neurology. Subjects and Methods: A prospective, observational, cross-sectional study was carried out in the neurology outpatient department of tertiary care teaching hospital. Data of patients above 18 years were recorded after obtaining their informed consent. The National Formulary of India (NFI) and British National Formulary (BNF) guidelines were used as tools for evaluation of the prevalence of off-label drug use. Results: A total of 709 drugs were recorded from the prescription data of 205 patients collected in the duration of 2 months. The results reported 145 (20.45%) and 317 (44.71%) drugs as off-label as per the NFI and BNF, respectively. Prescriptions with minimum 1 off-label drug use were 78.05% - BNF and 46.83% - NFI. The indication was one of the most common causes of drugs being off-label. Out of the total 317 off-label drug uses reported, 84 were unlicensed drug use as per the BNF. There is strong and positive correlation established between the age of the patients, number of drugs prescribed, and total off-label drugs prescribed per patient in the given study. The most common off-label drug use noted was with clonazepam and amitriptyline. Conclusion: Off-label prescriptions practice is common in the field of neurology. © 2019 Perspectives in Clinical Research | Published by Wolters Kluwer - Medknow.

关键词： Alzheimer’s disease   cannabinoid   cannabinoid type 2 receptor   ischemic stroke   neuroprotection   Parkinson disease  

摘要： Cannabinoids have long been used for their psychotropic and possible medical properties of symptom *** the past few years,a vast literature shows that cannabinoids are neuroprotective under different pathological *** of the effects of cannabinoids are mediated by the well-characterized cannabinoid receptors,the cannabinoid type 1 receptor (CB1R) and cannabinoid type 2 receptor (CB2R).Even though CB1Rs are highly expressed in the central nervous system (CNS),the adverse central side effects and the development of tolerance resulting from CB1R activation may ultimately limit the clinical utility of CB1R *** contrast to the ubiquitous presence of CB1Rs,CB2Rs are less commonly expressed in the healthy CNS but highly upregulated in glial cells under neuropethological *** studies have provided robust evidence that CB2Rs seem to be involved in the modulation of different neurological *** this paper,we summarize the current knowledge regarding the protective effects of CB2R activation against the development of neurological diseases and provide a perspective on the future of this field.A better understanding of the fundamental pharmacology of CB2R activation is essential for the development of clinical applications and the design of novel therapeutic strategies.

关键词： 神经病学   专业课程   思政教育   教学改革  

摘要： 在神经病学专业课程设置中融入思政教育内容,能够保证思想政治理论教学与专业课程教学之间形成协同作用,进而提高学生的学习积极性和主动性,使其更加认可中华文化,最大限度提升学生对于社会主义核心价值观学习的热情。内容对神经病学专业课程与思政教育融合的改革目的、措施和结果进行了分析。

摘要： 一、简介广东医科大学神经病学研究所是广东医科大学神经病学教学与科研的重要基地,始建于1998年,2002年神经病学成为硕士学位授权点,2011年升格为神经病学研究所,同年获批为广东省"十二五"神经变性疾病与衰老研究医学重点实验室,2012年获批为广东省衰老相关心脑疾病重点实验室和广东省特色重点学科。研究所在赵斌教授的领导下,成功组建了一支年富力强、具有自主创新能力的研究团队。

摘要： 《国际神经病学神经外科学杂志》创刊于1974年,由教育部主管,中南大学、中南大学湘雅医院主办。是目前国内唯一一本同时涵盖神经病学和神经外科学的专业学术期刊。本刊为"中国科技核心期刊(中国科技论文统计源期刊)",并且进入"《中国高质量科技期刊分级目录》T3区"。国内外公开发行,刊号为ISSN2096-921X(online),ISSN 1673-2642(print),CN43-1456/R,大16开,96页,双月刊,邮发代号42-11。每期定价20元,全年定价120元。《国际神经病学神经外科学杂志》以促进国内外学术的双向交流,为中国神经科学走向世界搭建新的平台为宗旨。主要栏目有论著、临床研究、专家讲座、综述等。欢迎国内神经内科、神经外科及相关专业医务人员积极投稿和订阅本刊。

关键词： Evidence-based design   Healthcare design   Human behaviour   Indoor environmental quality   Environment and Behaviour  

摘要： Single-patient rooms are commonly recommended in acute hospital environments. People with neurological disorders, and those who are older, have complex clinical presentations requiring support and recovery for physical, cognitive, and social consequences of their brain injury, and/or chronic health problems. It is currently unknown what type of patient room, or what physical characteristics in such rooms, might be most desirable for the recovery of such people. We explored how hospital single-patient rooms are similar to or different from multi-bed rooms, and how the impact of room type has been measured in this group of people. A systematic mixed studies review was conducted to interrogate these questions. We identified 182 studies (mostly quantitative in design), 19 of which proceeded to formal data extraction. The findings show lack of clarity of salient physical characteristics in either room type for our review population. Importantly, apart from some signal of infection control benefits, our findings do not show evidence to support the use of single-patient rooms with older people and people with neurological disorders for other important outcomes. More investigation of the under-recognized potential of the patient room environment for shaping patient physical, cognitive, and social well-being in specific hospitalized populations is required.

关键词： 《临床神经病学杂志》   临床神经病学  

摘要： 《临床神经病学杂志》系国家级神经病学专业性学术刊物,由南京医科大学附属脑科医院主办。刊登内容以临床神经病学为主,兼及有关边缘学科。读者对象以从事临床神经病学专业的高、中级人员为主,也可供内科、儿科、眼科、五官科医师参阅。本刊的办刊宗旨是:面向临床,面向基层,注重实用,鼎力于提高我国临床神经科医师的专业理论及诊疗水平。