关键词： 病例讨论   医学专业   神经病学   学术交流平台   编辑部编辑   有奖征文启事   癫痫   学术期刊  

摘要： 癫痫是神经病学临床工作的热点、难点之一,作为癫痫学科学术交流平台的《癫痫杂志》于2015年7月创刊。《癫痫杂志》是由教育部主管,四川大学主办,《癫痫杂志》编辑部编辑出版的医学专业类学术期刊,系中国抗癫痫协会会刊。本刊分为论著、综述、Epilepsia专栏、病例讨论、世界舞台·中国好声音、纪要等栏目。为了更好地促进我国癫痫专业领域的科研进展,提高我国癫痫诊疗的规范化程度和学术水平,现特举办有奖征文活动。

关键词： 中文核心期刊要目总览   来源期刊   神经免疫学   科研成果   科研人员   中国学术期刊   中国免疫学会   神经病学  

摘要： 《中国神经免疫学和神经病学杂志》是全国唯一与神经免疫学相关的神经病学学术性期刊,由国家卫健委主管,北京医院、中国免疫学会神经免疫分会主办,国内外公开发行。本刊以从事神经免疫学和神经病学临床和科研人员等为主要读者对象,报道神经疾病领域尤其是神经免疫学领域的科研成果。本刊属《中文核心期刊要目总览(2017版)》收录期刊、中国科技论文统计源期刊、中国科技核心期刊、中国科技引文数据库来源期刊与中国学术期刊综合评价数据库来源期刊等。

关键词： 神经精神疾病   康复医学   精神病学   神经遗传学   神经病学   科研方法   科研成果   核心期刊  

摘要： 《中国神经精神疾病杂志》为我国神经病学与精神病学核心期刊,国内外公开发行。本刊以广大神经内科、神经外科、精神科及相关学科(包括神经生物学、神经遗传学及康复医学等)医师为主要读者,报道神经精神学科领域领先的科研方法、科研成果和临床诊疗经验,以及对神经精神疾病临床有指导意义的基础理论研究。一直被《中文核心期刊要目总览》、《中国科技论文统计源期刊》、中国科学引文数据库(CSCD)等收录为核心期刊。

关键词： gray matter volume   mCCA plus jICA   motor abnormalities   neurological soft signs   resting-state functional MRI   schizophrenia spectrum disorders  

摘要： Neurological soft signs (NSS) comprise a broad range of subtle neurological deficits and are considered to represent external markers of sensorimotor dysfunction frequently found in mental disorders of presumed neurodevelopmental origin. Although NSS frequently occur in schizophrenia spectrum disorders (SSD), specific patterns of co-altered brain structure and function underlying NSS in SSD have not been investigated so far. It is unclear whether gray matter volume (GMV) alterations or aberrant brain activity or a combination of both, are associated with NSS in SSD. Here, 37 right-handed SSD patients and 37 matched healthy controls underwent motor assessment and magnetic resonance imaging (MRI) at 3 T. NSS were examined on the Heidelberg NSS scale. We used a multivariate data fusion technique for multimodal MRI data-multiset canonical correlation and joint independent component analysis (mCCA + jICA)-to investigate co-altered patterns of GMV and intrinsic neural fluctuations (INF) in SSD patients exhibiting NSS. The mCCA + jICA model indicated two joint group-discriminating components (temporoparietal/cortical sensorimotor and frontocerebellar/frontoparietal networks) and one modality-specific group-discriminating component (p < .05, FDR corrected). NSS motor score was associated with joint frontocerebellar/frontoparietal networks in SSD patients. This study highlights complex neural pathomechanisms underlying NSS in SSD suggesting aberrant structure and function, predominantly in cortical and cerebellar systems that critically subserve sensorimotor dynamics and psychomotor organization.

关键词： Cardiogenic shock   Neurological outcome   Short-term mechanical circulatory support   ECMO   Survival   Mechanical circulatory support   Impella  

摘要： OBJECTIVES: Peripheral venoarterial extracorporeal life support (ECLS) for the treatment of cardiogenic shock has shown to improve survival but is associated with complications. However, if the patient cannot be weaned from ECLS, their therapy options are limited. Although durable left ventricular assist device implantation might be an option in such cases, an unclear neurological outcome is often a contraindication. We hypothesize that Impella 5.0 therapy provides sufficient circulatory support while avoiding ECLS-related complications, thereby allowing for an adequate evaluation of a patient's neurological state and facilitating further treatment options. METHODS: We retrospectively reviewed data from 22 ECLS patients (mean age 56.5 +/- 10.7 years) with an unclear neurological status who underwent Impella 5.0 implantation between January 2016 and July 2018 in our institution. Neurological status was evaluated on a daily basis using the cerebral performance category score and the modified Rankin scale. RESULTS: Sixteen patients (72.7%) were resuscitated before ECLS implantation and 13 patients (59.1%) had acute myocardial infarction. The mean duration on ECLS before Impella 5.0 implantation was 9.3 +/- 1.7 days. All patients were successfully weaned from ECLS by Impella 5.0 implantation via the axillary artery. The mean duration on Impella 5.0 was 16.3 +/- 4.7 days. In surviving patients, both quantitative measurements of cerebral performance improved after 30 days compared to the baseline (P < 0.01). Six patients (27.3%) were bridged to a durable left ventricular assist device. In 9 patients (40.9%), myocardial function recovered during Impella 5.0 support and the device was successfully explanted. The 30-day survival rate was 68.2%. CONCLUSIONS: Impella 5.0 support provides a bridge-to-decision option for patients following ECLS implantation and leads to left ventricular unloading. It allows further evaluation of a patient's neurological situation and facilitates

摘要： Cholinergic dysfunction is involved in a range of neurological and psychiatric disorders, including schizophrenia, dementia and Lewy body disease (LBD), leading to widespread use of cholinergic therapies. However, such drugs have focused on increasing the availability of acetylcholine (ACh) generally, with relatively little work done on the muscarinic system and specific muscarinic receptor subtypes. In this review, we provide an overview of the major cholinergic pathways and cholinergic muscarinic receptors in the human brain and evidence for their dysfunction in several neurological and psychiatric disorders. We discuss how the selectivity of cholinergic system dysfunction suggests that targeted cholinergic therapeutics to the muscarinic receptor subtypes will be vital in treating several disorders associated with cognitive dysfunction and behavioural and psychological symptoms.

关键词： hyponatremia   neurological manifestations   portal hypertension   terlipressin  

摘要： What is known and objective Terlipressin has been shown to be effective in controlling variceal bleeding and decreasing associated mortality. Terlipressin is a synthetic analogue of vasopressin and is safer than arginine vasopressin;it induces selective vasoconstriction by stimulating the vasopressin V1 receptors that are predominantly located in the splanchnic tissues. However, severe hyponatraemia may occur during terlipressin treatment, resulting in neurological manifestations. Case summary We describe two patients who presented a marked decrease in serum sodium levels and developed obvious neurological manifestations after receiving terlipressin therapy. Although the two patients were given sodium supplementation, their serum sodium levels continually declined. After the discontinuation of terlipressin, their serum sodium levels rapidly recovered to normal limits, and the neurological manifestations subsequently disappeared in both patients. What is new and conclusion Some studies have reported hyponatraemia as a side effect of terlipressin;however, severe hyponatraemia with neurological manifestations has rarely been reported. We presented the cases of 2 patients with obvious neurological manifestations after receiving terlipressin therapy. Severe hyponatraemia may develop in patients treated with terlipressin, resulting in associated neurological symptoms. Therefore, the close monitoring of serum sodium is necessary.

摘要： The 'non-linear' genome, or the spatial proximity of non-contiguous sequences, emerges as an important regulatory layer for genome organization and function, including transcriptional regulation. Here, we review recent genome-scale chromosome conformation mappings ('Hi-C') in developing and adult human and mouse brain. Neural differentiation is associated with widespread remodeling of the chromosomal contact map, reflecting dynamic changes in cell-type-specific gene expression programs, with a massive (estimated 20-50%) net loss of chromosomal contacts that is specific for the neuronal lineage. Hi-C datasets provided an unexpected link between locus-specific abnormal expansion of repeat sequences positioned at the boundaries of self-associating topological chromatin domains, and monogenic neurodevelopmental and neurodegenerative disease. Furthermore, integrative cell-type-specific Hi-C and transcriptomic analysis uncovered an expanded genomic risk space for sequences conferring liability for schizophrenia and other cognitive disease. We predict that spatial genome exploration will deliver radically new insights into the brain nucleome in health and disease.

摘要： Colour vision impairments have been identified in early stages of neurological disorders such as Parkinson′s disease, and the relative contribution of retinal versus cortical mechanisms remains a matter of intense debate. Similar considerations can be raised concerning other neurological disorders such as Multiple Sclerosis (with or without optic neuritis) and Alzheimer's Disease. This may be due to the fact the retina may mirror the brain in terms of pathology, or suffer from retrograde degeneration in the case of multiple sclerosis. Moreover cortical changes secondary to retinal disease, such as glaucoma and diabetic retinopathy may also bias colour perception. Here we review current evidence concerning the relative role of the retina in colour vision deficits in a broad range of neurological and ophthalmological disorders. In particular, we discuss the potential role of colour vision measures as disease related biomarkers that can be used for diagnostic, prognostic and treatment effects assessment. [ABSTRACT FROM AUTHOR]

关键词： POEMS syndrome   vascular endothelial growth factor (VEGF)   peripapillary retinal thickness (pRT)   autologous peripheral blood stem cell transplantation   predictive marker  

摘要： Purpose: We present our findings in two cases of polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes (POEMS) syndrome, one with and one without optic disc edema (ODE), after autologous peripheral blood stem cell transplantation. Method: Both patients underwent an autologous peripheral blood stem cell transplantation. The peripapillary retinal thickness (pRT) was determined by spectral‐domain optical coherence tomography (SD‐OCT) to assess the degree of optic disc edema. The SD‐OCT examinations consisted of a 3.45 mm diameter circular scan centered on the optic disc. The pRT thickness was measured at the baseline and at 12 months after beginning the treatment. The serum level of VEGF was determined by enzyme‐linked immunosorbent assays (ELISAs) at the baseline and at 12 months after beginning the treatment. Neurological examinations, e.g., grip strength and compound muscle action potentials (cMAPs) of the upper limb, were also measured at the baseline and 12 months after the transplantation. Result: The pRT in the case without ODE was 310 μm at the baseline. At 12 months after the transplantation, the serum levels of VEGF decreased from 7050 to 511 pg/ml, the grip strength increased from 13 kg to 19 kg, and the cMAP amplitudes increased from 4.31 mV to 7.02 mV. On the other hand, the pRT in the case with severe ODE was 1167 μm at the baseline, and it did not change after the transplantation. The serum levels of VEGF decreased from 9060 pg/ml to 99 pg/ml after the transplantation, the grip strength decreased from 32 kg to 29 kg, and the amplitudes of the cMAP decreased from 2.16 mV to 0.32 mV at 12 months after the transplantation. Conclusion: These results suggest that the baseline degree of ODE before an autologous peripheral blood stem cell transplantation might be a predictive marker on the effectiveness of the transplantation on patients with the POEMS syndrome. However, further studies with a larger sample size are needed. Keywo