关键词： biomarkers   CSF   IL-8   inflammatory cytokines   multi-parametric assay   oligodendrocyte precursor cells   SCI  

摘要： The lack of reliable diagnostic and prognostic markers for spinal cord injured (SCI) patients is a severe obstacle in development and testing of new therapies, and it also impairs appropriate rehabilitation care. The sparse available data on the biochemical composition of cerebrospinal fluid (CSF) during the acute and/or chronic phase of the lesion provide, up until now, inconsistent results. In this pilot study, we then explored the possibility of combining a multi-parametric and bioinformatic analysis of CSF for its biological properties tested on different cells types, suitable for investigating inflammation and re-myelination. The patient enrollment was based on stringent inclusion criteria;that is, cervical and thoracic SCI trauma, CSF collection within 24 h of trauma, type of surgical approach for spine stabilization, and absence of steroid therapy before CSF collection. Eleven SCI patients and four healthy controls were included, and in three patients, CSF was also collected at 3 months after lesion. We identified 19 proteins among the 60 investigated cytokines, chemokines, growth factors, and structural biomarkers, which are transiently regulated 24 h after SCI. A bioinformatic analysis indicated that interleukin (IL)-6 and IL-10 are in the core of the interconnected net of activated proteins. Cell-based experiments indicate that CSF from SCI patients stimulates astroglia derivation from neural precursor cells, and an inverse correlation between IL-8 CSF level and oligodendrocyte precursor cells generated from neural stem cells was also observed. Results from this pilot study suggest that using a combined bioanalytic and biological approach to analyze SCI CSF at different times after injury could be a useful approach for identifying reliable diagnostic and prognostic markers in SCI.

关键词： 同仁医院   仁济医院   帕金森病   运动障碍   神经病学   王晓平   王玉平   国家自然基金  

摘要： 第六届国际帕金森病暨运动障碍学术研讨会于2019年10月11日至10月12日在上海隆重召开,本次会议由上海交通大学医学院附属同仁医院主办,由国际帕金森病及运动障碍学会(international movement disorder society,MDS)协办,本次会议得到了国家自然基金国际交流项目和王宽诚医学教育人才基金支持,为国家级继续教育项目。会议由世界(帕金森病)运动障碍协会亚太区AOS执委王晓平(上海)教授和王玉平(北京)教授担任大会主席,并邀请了安徽中医药大学神经病学研究所名誉所长杨任民教授、美国国立卫生研究院神经病学和卒中研究所主任Hallett M教授、世界(帕金森病)运动障碍协会常委及财务总监Louis Tan教授、世界(帕金森病)运动障碍协会前任亚太区AOS执委Tim Anderson教授(新西兰Otago大学运动障碍亚专业专家)担任名誉主席。来自德国、土耳其、新加坡、新西兰、乌克兰及中国台湾地区等的10余位知名专家及国内30余位专家应邀出席了本次会议。参会的还有来自全国各地相关领域的专家、临床医生等与会代表共计200余人。大会开幕式由上海交通大学医学院附属同仁医院王晓平教授主持,上海交通大学医学院附属同仁医院马骏院长、上海交通大学医学院附属仁济医院管阳太教授、安徽中医药大学神经病学研究所名誉所长杨任民教授致欢迎词。

关键词： 中华医学会   中华神经科杂志   神经科临床   神经病学   病例报告   学术会议   临床相关   会议投稿  

摘要： 中华神经科杂志将与2020年9月份在珠海召开的“中华医学会第23次全国神经病学学术会议”合作出版重点号(正刊,不是增刊)。凡向会议投稿的作者,可把没有发表过的、有关神经科临床或与临床相关的各类稿件(论著,病例报告,综述等)投到中华神经科杂志该期重点号发表。

关键词： 中华医学会   临床应用经验   神经科临床   癫痫学   神经电生理学   普及与提高   神经病学   学术刊物  

摘要： 一、本刊由中华医学会神经病学分会脑电图与癫痫学组和贵州医科大学联合主办.由贵州医科大学附属医院承办,是我国癫痫与临床神经电生理专业经批准国内外公开发行的学术刊物。本刊的宗旨是为我国癫痫学、临床神经电生理学及神经科临床工作者提供一个学术园地,为及时和充分地反映我国此学科的研究成果.推动此学科专业技术的进一步普及、健康发展和学术水平不断提高作出积极贡献。本刊的方针是普及与提高相结合,理论与实践相结合,刊载此专业临床应用经验总结和基础研究的文稿,力求对工作实践有参考和指导作用。

摘要： Monte Carlo proton dose calculations requires mass densities calculated from the patient CT image. This work investigates the impact of different single-energy CT (SECT) and dual-energy CT (DECT) to density conversion methods in proton dose distributions for brain tumours. Material and methods: Head CT scans for four patients were acquired in SECT and DECT acquisition modes. Commercial software was used to reconstruct DirectDensity((TM)) images in Relative Electron Densities (RED, ) and to obtain DECT-based pseudo-monoenergetic images (PMI). PMI and SECT images were converted to RED using piecewise linear interpolations calibrated on a head-sized phantom, these fits were referred to as "PMI2RED" and "CT2RED". Two DECT-based calibration methods ("Hunemohr-15it" and "Saito-15it") were also investigated. images were converted to mass-densities () to investigate differences and one representative patient case was used to make a proton treatment plan. Using CT2RED as reference method, dose distribution differences in the target and in five organs-at-risk (OARs) were quantified. Results: In the phantom study, Saito-15it and Hunemohr-15it produced the lowest root-mean-square error (0.7%) and DirectDensity((TM)) the highest error (2.7%). The proton plan evaluated in the Saito-15it and Hunemohr-15it datasets showed the largest relative differences compared to initial CT2RED plan down to -6% of the prescribed dose. Compared to CT2RED, average range differences were calculated: -0.1 +/- 0.3 mm for PMI2RED;-0.8 +/- 0.4 mm for Hunemohr-15it, and -1.2 +/- 0.4 mm for Saito-15it. Conclusion: Given the wide choice of available conversion methods, studies investigating the density accuracy for proton dose calculations are necessary. However, there is still a gap between performing accuracy studies in reference phantoms and applying these methods in human CT images. For this treatment case, the PMI2RED method was equivalent to the conventional CT2RED method in terms of dose distributi

关键词： Carbon   nanotubes   Nervous   system   diseases   Drug   delivery   Therapeutic   drug   Inherent   medication   Toxicity  

摘要： Nowadays,nanotechnology is revolutionizing the approaches to different fields from manufacture to *** nanotubes(CNTs)as promising candidates in nanomedicine have great potentials in developing novel entities for central nervous system pathologies,due to their excellent physicochemical properties and ability to interface with neurons and neuronal ***,most of the studies mainly focused on the drug delivery and bioimaging applications of CNTs,while neglect their application prospects as therapeutic drugs *** present,the relevant reviews are not available *** we summarized the latest advances on the biomedical and therapeutic applications of CNTs in vitro and in vivo for neurological diseases treatments as inherent therapeutic *** biological mechanisms of CNTs-mediated bio-medical effects and potential toxicity of CNTs were also intensely *** is expected that CNTs will exploit further neurological applications on disease therapy in the near future.

关键词： 神经精神疾病   康复医学   精神病学   神经遗传学   神经病学   科研方法   科研成果   核心期刊  

摘要： 《中国神经精神疾病杂志》为我国神经病学与精神病学核心期刊,国内外公开发行。本刊以广大神经内科、神经外科、精神科及相关学科(包括神经生物学、神经遗传学及康复医学等)医师为主要读者,报道神经精神学科领域领先的科研方法、科研成果和临床诊疗经验,以及对神经精神疾病临床有指导意义的基础理论研究。一直被《中文核心期刊要目总览》、《中国科技论文统计源期刊》、中国科学引文数据库(CSCD)等收录为核心期刊。

关键词： blood   biomarker   neurology   outcome   SCI  

摘要： There is increasing interest in the identification of biomarkers that could predict neurological outcome following a spinal cord injury (SCI). Although initial American Spinal Injury Association (ASIA) Impairment Scale (AIS) grade is a good indicator of neurological outcome, for the patient and clinicians, an element of uncertainty remains. This preliminary study aimed to assess the additive potential of routine blood analytes following principal component analysis (PCA) to develop prognostic models for neurological outcome following SCI. Routine blood and clinical data were collected from SCI patients (n = 82) and PCA used to reduce the number of blood analytes into related factors. Outcome neurology was obtained from AIS scores at 3 and 12 months post-injury, with motor (AIS and total including all myotomes) and sensory (AIS, touch and pain) abilities being assessed individually. Multiple regression models were created for all outcome measures. Blood analytes relating to "liver function" and "acute inflammation and liver function" factors were found to significantly increase prediction of neurological outcome at both 3 months (touch, pain, and AIS sensory) and at 1 year (pain, R-2 increased by 0.025 and total motor, R-2 increased by 0.016). For some models "liver function" and "acute inflammation and liver function" factors were both significantly predictive, with the greatest combined R-2 improvement of 0.043 occurring for 3 month pain prediction. These preliminary findings support ongoing research into the use of routine blood analytes in the prediction of neurological outcome in SCI patients.

摘要： 《国际神经病学神经外科学杂志》创刊于1974年,由教育部主管,中南大学和中南大学湘雅医院主办。是目前国内唯——本同时涵盖神经病学和神经外科学两个相联学科的专业学术期刊。本刊被收录为“中国科技核心期刊(中国科技论文统计源期刊)”。

关键词： 医学人文教育   CBL   全科医师   规范化培训   神经病学  

摘要： 目的探讨实施以病例为基础的教学法(CBL)联合人文教学在全科医师规范化培训(全科规培)学员神经病学教学中的应用效果。方法选取进入蚌埠医学院第一附属医院进行全科医师规范化培训的2017级全科规培学员80人作为研究对象,随机分为实验组和对照组各40人,实验组采用CBL联合医学人文教学的教学模式,对照组采用LBL教学模式。课程结束后,测试2组学员的基础理论知识和实践应用能力,并以问卷形式调查学员对教学模式的主观量化评分。结果实验组学员基础理论知识成绩和实践应用能力考核得分均高于对照组(P<0.05),问卷调查结果显示实验组学员的人文理念、学习主动性、沟通能力、医患共同参与诊疗意识、分析问题能力、诊疗能力明显高于对照组(P<0.05)。结论CBL联合人文教学的教学模式可加强学员主动学习和沟通能力,促使学员与患者在充满人文关怀的氛围中共同参与疾病的诊治,并提高分析问题和诊疗能力。