关键词： Gene therapy   gene delivery   neurological diseases   CRISPER   Cas9 system   viral vectors   non-viral vectors   Autism Spectrum disorder  

摘要： Major advancements in targeted gene therapy have opened up avenues for the treatment of major neurological disorders through a range of versatile modalities varying from expression of exogenous to suppression of endogenous genes. Recent technological innovations for improved gene sequence delivery have focussed on highly specific viral vector designs, plasmid transfection, nanoparticles, polymer-mediated gene delivery, engineered microRNA and in vivo clustered regulatory interspaced short palindromic repeats (CRISPR)-based therapeutics. These advanced techniques have profound applications in treating highly prevalent neurological diseases and neurodevelopmental disorders including Parkinson's disease, Alzheimer's disease and autism spectrum disorder, as well as rarer diseases such as amyotrophic lateral sclerosis (ALS), spinal muscular atrophy, lysosomal storage diseases, X-linked adrenoleukodystrophy and oncological diseases. In this article, we present an overview of the latest advances in targeted gene delivery and discuss the challenges and future direction of gene therapy in the treatment of neurological disorders.

关键词： Vesicles   X-rays   Lipids   Membranes   Mixtures  

摘要： Ethanolamine plasmalogen (EtnPLA) is a conical-shaped ether lipid and an essential component of neurological membranes. Low stability against oxidation limits its study in experiments. The concentration of EtnPLA in the bilayer varies depending on cell type and disease progression. Here we report on mixed bilayers of 1-palmitoy1-2-oleoyl-sn-glycero-3-phosphocholine (POPC) and 1-(1Z-octadecenyl)-2-oleoyl-sn-glycero-3-phosphoethanolamine (C18(Plasm)-18:1PE, PLAPE), an EtnPLA lipid subtype, at mole ratios of 2:1, 1:1, and 1:2. We present X-ray diffuse scattering (XDS) form factors F(q(z)) from oriented stacks of bilayers, related electron-density profiles, and hydrocarbon chain NMR order parameters. To aid future research on EtnPLA lipids and associated proteins, we have also extended the CHARMM36 all-atom force field to include the PLAPE lipid. The ability of the new force-field parameters to reproduce both X-ray and NMR structural properties of the mixed bilayer is remarkable. Our results indicate a thickening of the bilayer upon incorporation of increasing amounts of PLAPE into mixed bilayers, a reduction of lateral area per molecule, and an increase in lipid tail-ordering. The lateral compressibility modulus (K-A) calculated from simulations yielded values for PLAPE similar to POPC.

关键词： nervous system disorders   denmark   suicide  

摘要： This population epidemiology study uses Danish registry data to examine associations between neurological disorders and higher suicide rates from 1980 through 2016. Question Is there an association between neurological disorders and a higher risk of death by suicide? Findings In this retrospective cohort study that included 7300395 persons in Denmark from 1980 through 2016, there was a significantly higher rate of suicide among those with a diagnosed neurological disorder than all other persons (44.0 per 100000 person-years vs 20.1 per 100000 person-years, adjusted incidence rate ratio, 1.8). Meaning In Denmark, having a diagnosis of a neurological disorder was associated with a small but statistically significant increased risk of death by suicide. Importance Neurological disorders have been linked to suicide, but the risk across a broad spectrum of neurological disorders remains to be assessed. Objectives To examine whether people with neurological disorders die by suicide more often than other people and to assess for temporal associations. Design, Setting, and Participants Nationwide, retrospective cohort study on all persons 15 years or older living in Denmark, from 1980 through 2016 (N = 7300395). Exposures Medical contact for head injury, stroke, epilepsy, polyneuropathy, diseases of myoneural junction, Parkinson disease, multiple sclerosis, central nervous system infections, meningitis, encephalitis, amyotrophic lateral sclerosis, Huntington disease, dementia, intellectual disability, and other brain diseases from 1977 through 2016 (n = 1248252). Main Outcomes and Measures Death by suicide during 1980-2016. Adjusted incidence rate ratio (IRRs) were estimated using Poisson regressions, adjusted for sociodemographics, comorbidity, psychiatric diagnoses, and self-harm. Results Of the more than 7.3 million individuals observed over 161935233 person-years (49.1% males), 35483 died by suicide (median duration of follow-up, 23.6 years;interquartile range, 10.0-37.0

关键词： 文献计量学   《中文核心期刊要目总览》   核心期刊   神经病学   精神病学   专家评审   《中华老年心脑血管病杂志》   通知  

摘要： 《中华老年心脑血管病杂志》主编:我们谨此郑重通知:依据文献计量学的原理的方法,经研究人员对相关文献的检索、统计和分析,以及学科专家评审,贵刊《中华老年心脑血管病杂志》入编《中文核心期刊要目总览》2017年版(即第8版)之“神经病学与精神病学”类的核心期刊。

关键词： artificial   urinary   sphincter   female   stress   incontinence   penile   prosthesis   implant   revision   surgery   spinal   cord   injury   urinary   incontinence  

摘要： The artificial urinary sphincter(AUS)remains the standard of care in men with severe stress urinary incontinence(SUI)following prostate surgery and *** the current AUS provides an effective,safe,and durable treatment option,it is not without its limitations and complications,especially with regard to its utility in some“high-risk”*** article provides a critical review of relevant publications pertaining to AUS surgery in specific high-risk groups such as men with spinal cord injury,revision cases,concurrent penile prosthesis implant,and female *** discussion of each category includes a brief review of surgical challenge and a practical action-based set of *** increased understandings of the pathophysiology of various SUI cases coupled with effective therapeutic strategies to enhance AUS surgery continue to improve clinical outcomes of many patients with SUI.

关键词： 审稿专家   审稿人   临床神经病学   编辑部   编委   杂志   保质保量   年度  

摘要： 在2019年度,《临床神经病学杂志》得益于各位编委和审稿人的大力支持,保质保量地完成了审稿任务。本刊编辑部在此向以下各位审稿专家表示诚挚的谢意!

关键词： 中文核心期刊   来源期刊   科研人员   中国学术期刊   中国免疫学会   神经免疫学   学术性期刊   普及与提高  

摘要： 《中国神经免疫学和神经病学杂志》(双月刊)是全国惟一与神经免疫学相关的神经病学学术性期刊,由国家卫健委主管,北京医院、中国免疫学会神经免疫分会主办,国内外发行。本刊以服务于广大医务人员特别是神经免疫学工作者、神经科临床和科研人员等为宗旨,并兼顾普及与提高。本刊属中文核心期刊、中国科技论文统计源期刊、中国科技核心期刊、中国科技引文数据库来源期刊与中国学术期刊综合评价数据库来源期刊。

关键词： 《临床神经病学杂志》   编辑委员会  

关键词： 中国医师协会   专委会委员   神经病学   西部论坛   优秀青年人才   留美博士   神经内科医师   老年学  

摘要： 陈莉芬,女,医学博士,主任医师,教授,硕士研究生导师,留美博士后,重庆医科大学附属第二医院神经内科副主任。目前担任中国医师协会神经内科分会脑与脊髓损害专委会委员,中国医师协会神经内科医师分会西部论坛专家委员会委员,中国整合医学神经内科专委会委员,重庆市医学会神经病学专委会青年委员会副主委,重庆市老年学学会心脑血管专委会委员,医院首批“人才工程”优秀青年人才。

关键词： 神经精神疾病   全国性学术会议   精神病学   临床荟萃   神经内科   精神科   神经病学   被引频次  

摘要： 由国家教育部主管、中山大学主办的《中国神经精神疾病杂志》创刊于1975年,是国内神经病学、精神病学领域内具有重要影响力的专业学术性核心期刊,被引频次及影响因子居临床医学期刊前列。我刊主要报道我国神经内科、神经外科、精神科临床和基础研究的新成果,介绍相关领域研究的新进展,推广先进的诊疗技术,组织专题学术讨论和召开全国性学术会议。辟有包括专家论坛、论著、短著述、研究简报、临床荟萃、讲座、综述、疑难病例讨论等诸多栏目,全面、实时地反映最新的学术思想和临床经验,其从基础到临床的广阔领域给致力于神经科学发展的研究者们提供了博大的舞台。