关键词： 学术不端行为   科技期刊学术不端文献检测系统   临床神经病学   文字复制比   辨别能力   一稿多投   中国学术文献网络出版总库   学术不端文献  

摘要： 为了提高编辑部对于学术不端文献的辨别能力,端正学风,维护作者权益,《临床神经病学杂志》日前已正式启用“科技期刊学术不端文献检测系统”,对来稿进行逐篇检查。该系统以《中国学术文献网络出版总库》为全文比对数据库,可检测抄袭与剽窃、伪造、篡改、不当署名、一稿多投等学术不端文献,论文的文字复制比不应高于20%。如查出作者所投稿件存在上述学术不端行为,本刊将立即做退稿处理。

关键词： TBI   Neurological function   Nitroxide   Antioxidant   Mitophagy  

摘要： Research has attributed tissue damage post-traumatic brain injury (TBI) to two-pronged effects, increased reactive oxygen species (ROS) and impairment of endogenous antioxidant defence systems, underpinned by manganese superoxide dismutase (MnSOD). Novel antioxidant nitroxides have been shown to mimic MnSOD to ameliorate oxidative stress related disorders. This study aimed to investigate the effects of two nitroxides, CTMIO and DCTEIO, on the neurological outcomes following moderate TBI in rats induced by a weight drop device. The rats were immediately treated with CTMIO and DCTEIO (40 mM in drinking water) post-injury for up to 2 weeks. The brains were histologically examined at 24 h and 6 weeks post injury. DCTEIO reduced the lesion size at both 24h and 6 weeks, with normalised performance in sensory, motor and cognitive tests at 24h post-injury. Astrogliosis was heightened by DCTEIO at 24h and still elevated at 6 weeks in this group. In TBI brains, cellular damage was evident as reflected by changes in markers of mitophagy and autophagy (increased fission marker dynamin-related protein (Drp)-1, and autophagy marker light chain 3 (LC3)A/B and reduced fusion marker optic atrophy (Opa)-1). These were normalised by DCTEIO treatment. CTMIO, on the other hand, seems to be toxic to the injured brains, by increasing injury size at 6 weeks. In conclusion, DCTEIO significantly improved tissue repair and preserved neurological function in rats with TBI possibly via a mitophagy mechanism. This study provides evidence for DCTEIO as a promising new option to alleviate lesion severity after moderate TBI, which is not actively treated.

关键词： 编辑出版工作   临床神经病学   新一届编委会   期刊   献计献策   杂志   第七届   委员会  

摘要： 截至2018年底,《临床神经病学杂志》第六届编辑委员会的任期已经届满。为更好地促进期刊的发展,《临床神经病学杂志》成立了第七届编辑委员会。期待新一届编委会能够继续帮助和支持编辑部的工作,为本刊献计献策。自《临床神经病学杂志》第六届编辑委员会成立以来,编委会全体成员对《临床神经病学杂志》的编辑出版工作作出了极大的贡献。

关键词： 神经免疫学   来源期刊   神经病学   中国学术期刊   中国免疫学会   科研成果   科研人员   临床病理讨论  

摘要： 《中国神经免疫学和神经病学杂志》是全国惟一与神经免疫学相关的神经病学学术性期刊,由卫健委主管,北京医院、中国免疫学会神经免疫分会主办,国内外公开发行。本刊以从事神经免疫学和神经病学临床和科研人员等为主要读者对象,报道神经疾病领域尤其是神经免疫学领域的科研成果。本刊属中国科技论文统计源期刊、中国科技核心期刊、中国科技引文数据库来源期刊与中国学术期刊综合评价数据库来源期刊等。本刊除辟有围绕与神经病学和神经免疫学相关疾病临床与基础研究方面的论著、述评、综述、进展、专论、讲座、临床病理讨论、疑难病例报告与讨论、论著摘要、研究简报、短篇报道等栏目外,还将设立神经免疫学发展史及神经科专家、研究生园地、问题解答等栏目。

关键词： 办公系统   在线注册   登录系统   邮件主题   网址   确认书   网站首页   在线提交  

摘要： 1.请打开本刊网址(http://***),点击“投稿及审稿办公系统”,进行在线注册。2.注册后登录系统,并以第一作者的中文姓名在线提交稿件(请勿以通讯作者或姓名拼音提交稿件)。3.在网站首页下载中心下载《版权转让确认书》,签字并加盖公章后拍照或扫描成电子版发至2105933141@***,并在邮件主题中注明“第一作者姓名”及“投稿”字样,如“张三-投稿”。

关键词： CSF1R   functional recovery   microglia   neurodegeneration   neuroinflammation   traumatic brain injury  

摘要： Chronic neuroinflammation with sustained microglial activation occurs following severe traumatic brain injury (TBI) and is believed to contribute to subsequent neurodegeneration and neurological deficits. Microglia, the primary innate immune cells in brain, are dependent on colony stimulating factor 1 receptor (CSF1R) signaling for their survival. In this preclinical study, we examined the effects of delayed depletion of chronically activated microglia on functional recovery and neurodegeneration up to 3 months postinjury. A CSF1R inhibitor, Plexxikon (PLX) 5622, was administered to adult male C57BL/6J mice at 1 month after controlled cortical impact to remove chronically activated microglia, and the inhibitor was withdrawn 1-week later to allow for microglial repopulation. Following TBI, the repopulated microglia displayed a ramified morphology similar to that of Sham uninjured mice, whereas microglia in vehicle-treated TBI mice showed the typical chronic posttraumatic hypertrophic morphology. PLX5622 treatment limited TBI-associated neuropathological changes at 3 months postinjury;these included a smaller cortical lesion, reduced hippocampal neuron cell death, and decreased NOX2-and NLRP3 inflammasome-associated neuroinflammation. Furthermore, delayed depletion of chronically activated microglia after TBI led to widespread changes in the cortical transcriptome and altered gene pathways involved in neuroinflammation, oxidative stress, and neuroplasticity. Using a variety of complementary neurobehavioral tests, PLX5622-treated TBI mice also had improved long-term motor and cognitive function recovery through 3 months postinjury. Together, these studies demonstrate that chronic phase removal of neurotoxic microglia after TBI using CSF1R inhibitors markedly reduce chronic neuroinflammation and associated neurodegeneration, as well as related motor and cognitive deficits.

关键词： 中国医师协会   帕金森   诊疗中心   神经内科医师   临床医生   行为学检测   神经病学   影像学检查  

摘要： 帕金森一站式诊疗专病中心集体液检测、行为学检测、影像学检查等为一体,集临床医生和神经病学专家于一堂。4月11日是世界帕金森日,当天,由上海交通大学医学院附属瑞金医院(以下简称"瑞金医院")神经内科牵头.中国医师协会神经内科医师分会指导成立的"中国首家帕金森一站式诊疗专病中心暨中国帕金森诊疗培训基地"在瑞金医院建成启动。

关键词： 神经内科   硕士生导师   特色专科   神经病学   出院病人   防治中心   医疗组   科室  

摘要： 贵州医科大学附属医院神经内科成立于1956年,由我省著名神经病学专家卢亮教授创建。经过半个多世纪的发展,目前我科室已拥有4个病区,5个医疗组,共有病床120张,成为集医疗、教学、科研为一体的特色专科。现年出院病人近4000余人。门诊年平均接诊病人35000余人次。科室有医护技人员85人,其中具有高级职称20人,博士5人,硕士17人,硕士生导师9人。

关键词： Monoacylglycerol   lipases   2-Arachidaoylglycerol   Arachidonic   acid   Drug   discovery   Cancer   Neuroinflammation   Metabolic   syndrome  

摘要： Monoacylglycerol lipase(MAGL)is a serine hydrolase that plays a crucial role catalysing the hydrolysis of monoglycerides into glycerol and fatty *** links the endocannabinoid and eicosanoid systems together by degradation of the abundant endocannabinoid 2-arachidaoylglycerol into arachidonic acid,the precursor of prostaglandins and other inflammatory *** inhibitors have been considered as important agents in many therapeutic fields,including anti-nociceptive,anxiolytic,antiinflammatory,and even ***,ABX-1431,a first-in-class inhibitor of MAGL,is entering clinical phase 2 studies for neurological disorders and other *** review summarizes the diverse(patho)physiological roles of MAGL and will provide an overview on the development of MAGL *** a large number of MAGL inhibitors have been reported,novel inhibitors are still required,particularly reversible ones.

关键词： 一稿两用   学位论文   共识性   一稿两投   临床神经病学   诊断标准   文稿   新闻报道类  

摘要： 为维护本刊声誉和广大读者的利益,现对一稿两投和一稿两用问题的处理声明如下:(1)本声明中所涉及的文稿均指原始研究的报告或尽管2篇文稿在文字的表达和讨论的叙述上可能存在某些不同之处,但这些文稿的主要数据和图表是相同的。所指文稿不包括重要会议的纪要、学位论文、疾病的诊断标准和防治指南、有关组织达成的共识性文件、新闻报道类文稿以及在一种刊物发表过摘要或初步报道而将全文投向另一种期刊的文稿。