关键词： Double aortic arch   Intraoperative neurological monitoring system   Recurrent laryngeal nerve   Case report  

摘要： Background Double aortic arch (DAA) is a congenital anomaly of the aorta. Esophageal cancer with DAA is rare, and consequently, the appropriate surgical approach has not been standardized. Herein, we report the utilization of intraoperative neurological monitoring (IONM) system to preserve the function of the recurrent laryngeal nerve. Case presentation A 79-year-old man with esophageal cancer was diagnosed with DAA incidentally. The descending aorta was located on the right side of the thoracic vertebrae. Safe dissection of the mediastinal lymph nodes was difficult using the right transthoracic approach because of the anatomical abnormalities. During surgery, we used cervical mediastinoscopy combined with the IONM system to preserve the bilateral recurrent laryngeal nerves. Severe complications, including recurrent nerve palsy, were not observed postoperatively. Conclusion IONM may be useful for evaluation of the function of the recurrent laryngeal nerve, and it would be suitable for atypical cases of esophageal cancer.

关键词： 网络教学   微课程   微信平台   神经病学   临床教学  

摘要： 浅析通过微课程和微信平台完成神经系统的临床教学。该文分析了网络教学的现状,阐述了微课程的形成与制作方法,微信平台的应用。结合实时列举了微课程和微信平台在神经病学临床教学的应用。

关键词： Spinal cord injury   Diet   Ketogenic   Proteomics   Nutrition therapy   High-protein diet   Low-carbohydrate diet  

摘要： Background Therapies that significantly improve the neurological and functional recovery of individuals with spinal cord injury (SCI) are still urgently needed. The ketogenic diet (KD) has been shown to improve forelimb motor function in an SCI rat model, likely by reducing inflammation and cell death in the spinal cord. Furthermore, our recent pilot study in patients with SCI showed that, compared with a standard hospital diet (SD), 5 weeks of KD started during acute care improved upper extremity motor function and reduced serum levels of a neuroinflammatory blood protein. The primary goals of the current study are to: 1) show the safety and feasibility of administering a KD during acute care for SCI;2) determine if consuming 5 weeks of a KD significantly improves motor and sensory functions, functional independence and glycemic control;and 3) quantify serum biomarkers that are linked to improvements in neurological recovery and functional independence via targeted proteomics. Methods/design In a single-masked, longitudinal, randomized, parallel-controlled study, a total of 60 eligible, acutely traumatic spinal cord injured (cervical 5 to thoracic 12) participants ranging in age from 18 to 60 years with American Spinal Injury Association impairment scale (AIS) grades A-C (AIS-A, sensorimotor complete;AIS-B, sensory incomplete/motor complete;and AIS-C, nonfunctional motor incomplete) are being enrolled. Neurological and functional examinations, resting energy expenditure, blood, urine, and stool collections, and protein analyses related to neurological recovery will be performed within 72 h of injury (baseline measure) and repeated after 5 weeks of KD or SD (discharge measure). We anticipate a completion rate of 80% with a total of 48 participants. Discussion Intervention with a more neuroprotective diet during acute care of SCI can be implemented anywhere in the world at low cost and without major regulatory hurdles. Better functional recovery will lead to a better

关键词： 中英文   神经病学  

关键词： 心血管病学   肾脏病学   神经病学   内分泌学   受体激动剂   糖代谢   临床获益   葛均波  

摘要： 近期,由葛均波、霍勇和李勇等教授牵头中国心血管病学、内分泌学、肾脏病学和神经病学专家组成的专家组发布了《改善心血管和肾脏结局的新型抗高血糖药物临床应用中国专家建议》。建议指出,在糖代谢患者调整药物的选择上,应该优先选择对心血管和肾脏具有明确临床获益证据的药物,包括胰高血糖素样肽-1(GLP-1)受体激动剂和钠-葡萄糖协同转运蛋白2(SGLT-2)抑制剂。

关键词： 神经病学   临床实习   教学方法   多媒体   微信平台  

摘要： 神经病学是一门抽象、复杂、专业性强的临床学科,传统教学模式已不能满足临床带教的需要。为提高神经内科教学质量,中国人民解放军总医院海南医院神经内科结合专科特点,利用微信平台辅助临床带教。在神经内科临床教学实践中采用微信公众号、微信交流群、网络直播授课等多媒体教学,运用微信平台快捷通信、有效反馈、协同协作等特点,弥补了传统教学方式重教轻学、重理论轻实践等弊端,进一步调动了学生学习的积极性,在一定程度上改善了教学质量,提高了教学效率。

关键词： 微课   翻转课堂   实习教学   神经病学  

摘要： 神经疾病的理论知识相对抽象,很多实习医生在实习过程反映神经内科实习难,缺乏积极性、主动性。该研究基于微课及翻转课堂的优势,以及神经内科实习中突出的问题,借助基于微课的翻转课堂在神经内科实习过程中应用研究,充分利用其优势来提高教学质量,提高实习生对神经系统专科疾病的临床能力。

关键词： Nipah virus   henipavirus   ZsGreen1   Syrian golden hamster   in situ fluorescent imaging   lung   brain   central nervous system   neurological   respiratory  

摘要： Using a recombinant Nipah virus expressing a fluorescent protein (ZsG), we visualized virus tropism in the Syrian hamster model. We found that anatomical localization of fluorescence correlated to clinical signs;signal was primarily visualized in the respiratory tract in animals with acute-onset terminal disease, whereas central nervous system localization was seen in animals that succumbed with delayed disease onset. While polymerase chain reaction (PCR) detection corresponded well to ZsG signal, virus was only isolated from some lung, brain, liver, and kidney samples that were ZsG and/or PCR positive, and only from animals euthanized on or before 15 days post infection.