关键词： 神经精神疾病   康复医学   精神病学   神经遗传学   神经病学   科研方法   科研成果   核心期刊  

摘要： 《中国神经精神疾病杂志》为我国神经病学与精神病学核心期刊,国内外公开发行。本刊以广大神经内科、神经外科、精神科及相关学科(包括神经生物学、神经遗传学及康复医学等)医师为主要读者,报道神经精神学科领域领先的科研方法、科研成果和临床诊疗经验,以及对神经精神疾病临床有指导意义的基础理论研究。一直被《中文核心期刊要目总览》、《中国科技论文统计源期刊》、中国科学引文数据库(CSCD)等收录为核心期刊。

关键词： 神经毒理学   何凤生   劳动卫生   学科带头人   神经病学   医学家  

摘要： 何凤生院士是杰出的劳动卫生与职业医学家,是我国职业医学的开拓者和神经毒理学的学科带头人之一。她开创了我国劳动卫生与职业医学的新学科——职业神经病学,为保障工人、农民的职业健康作出了突出贡献。

关键词： 三尺讲台   肝豆状核变性   神经病学   名誉所长   人生历程   权威专家  

摘要： 九十年的人生历程,六十五年的从医从教生涯,他用热忱与汗水播撒出神经科领域的一片沃土.临床一线,三尺讲台,他造福患者无数,培养桃李满天下.他就是我国著名神经病学专家、中西医结合治疗肝豆状核变性(即Wilson病)的奠基人和该领域公认的最权威专家、安徽省医学会名誉会长、安徽中医药大学神经病学研究所名誉所长杨任民教授.

关键词： CAR T cell therapy   Chimeric antigen receptor   Neurotoxicity   Immune effector cell-associated neurotoxicity syndrome  

摘要： Purpose of Review Chimeric antigen receptor (CAR) T cells are a breakthrough therapeutic treatment for patients with relapsed and refractory hematologic malignancies. With two FDA-approved formulations and likely more to come, CAR T cell therapy is moving beyond clinical trials and into academic and community oncology practices throughout the country. Oncologists are tasked with understanding the indications for this treatment and the potential complications. Recent Findings In this review, we focus on the neurological toxicities associated with CAR T cell therapy. Neurotoxicity affects approximately half of patients treated with CAR T cells and can cause severe morbidity. We discuss the incidence, pathophysiology, and management of neurological complications of CAR T cells. CAR T cells are a breakthrough treatment for hematologic malignancies with considerable neurological toxicity that requires attention and management.

关键词： 北京大学出版社   核心期刊表   文献计量学   神经疾病   《中国图书馆分类法》   神经病学   精神病学   专家评审  

摘要： 《中国现代神经疾病杂志》主编:我们谨此郑重通知:依据文献计量学的原理和方法,经研究人员对相关文献的检索、统计和分析,以及学科专家评审,贵刊《中国现代神经疾病杂志》入编《中文核心期刊要目总览》2017年版(即第8版)之"神经病学与精神病学"类的核心期刊。该书由北京大学出版社出版。书中按《中国图书馆分类法》的学科体系,列出了78个学科的核心期刊表,并逐一对核心期刊进行了著录。

关键词： 中华医学会   医院神经科   循证医学证据   影像学技术   神经病学   脑血管病   医学影像技术   影像诊断  

摘要： 医学影像技术在脑血管病诊疗和研究中占有重要地位,2016年中华医学会神经病学分会、中华医学会神经病学分会脑血管病学组发布《中国脑血管病影像应用指南2016》.近年来随着影像学技术的迅猛发展和临床应用循证医学证据的不断增多,2016年版指南已不能满足临床需要,中华医学会神经病学分会及脑血管病学组组织专家修订并于日前正式发布《中国脑血管病影像应用指南2019》(简称“《指南2019》”).

关键词： 办刊宗旨   中国医师协会   神经疾病   神经解剖学   普及与提高   神经病学   专业期刊   神经内外科  

摘要： 《中国现代神经疾病杂志》为国家卫生健康委员会主管、中国医师协会主办的神经病学类专业期刊。办刊宗旨为:理论与实践相结合、普及与提高相结合,充分反映我国神经内外科临床科研工作重大进展,促进国内外学术交流。所设栏目包括述评、专论、论著、临床病理报告、应用神经解剖学、神经影像学、循证神经病学、流行病学调查研究、基础研究、临床研究、综述、临床医学图像、病例报告、临床病理(例)讨论、新技术新方法等。

关键词： 真实性评价   案例教学   神经病学   医学教学  

摘要： 为弥补临床医学教学中学生缺少实践锻炼机会,难以对学生临床技能进行实时有效评估的缺点,探讨将真实性评价下的案例教学法引入《神经病学》的课堂教学,将纯粹的阶段性评价改善为阶段性评价与形成性评价相结合,并运用临床教学案例的讨论,增强医学本科生运用课本理论知识解决临床实际诊断问题的能力。经调查,新的教学模式初步取得成功,并得到广大学生的好评。

关键词： Open field test   Tape removal test   Ladder test   Behavioral deficits   Cerebral ischemia reperfusion  

摘要： Aim The neuronal damage and accompanied functional deficits induced by cerebral ischemia are among the most common causes of disabilities in adults. Activation of subtypes of peroxisome proliferator-activated receptors (PPARs); PPAR-α and PPAR-γ have shown neuroprotective effects in different neurodegenerative diseases including stroke. Thus, this study aimed to compare the effects of two different agonists: PPAR-α (fenofibrate) and PPAR-γ (pioglitazone) as well as the effect of their combination in ameliorating post-ischemia behavioral *** Male Wistar rats were either pretreated with vehicle, fenofibrate (100 mg/kg/day p.o), pioglitazone (10 mg/kg/day p.o) or their combination for 14 days prior to bilateral common carotid artery occlusion followed by reperfusion for 24 hoursh. The sensory motor functions of rats were assessed, then rats were sacrificed to determine infarct volume and histopathological changes as well as oxidative stress, inflammatory and apoptotic markers in the brain *** findings Pre-treatment with fenofibrate and pioglitazone in addition to their combination improved neurobehavioral dysfunction, reduced cerebral infarct volume, attenuated inflammatory and apoptotic markers and ameliorated histopathological changes in I/R injured rats. The effect of pioglitazone in cerebral cortex was higher than its corresponding effect in fenofibrate while the combined administration of both drugs had additive neuroprotective effect and normalized inflammatory and apoptotic mediators in ischemic *** The study compared the neuroprotective effects of PPAR-α and PPAR-γ agonists, and tested the impact of their combination. We concluded that no additional benefits on the functional outcomes might be gained upon their combination.

关键词： COVID-19   Encephalitis   Guideline   Neuroscience   SARS-COV-2  

摘要： BACKGROUND: The coronavirus disease of 2019 (COVID-19), which is caused by infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has recently been designated a pandemic by the World Health Organization, affecting 2.7 million individuals globally as of April 25, 2020, with more than 187,000 deaths. An increasing body of evidence has supported central nervous system involvement. METHODS: We conducted a review of the reported data for studies concerning COVID-19 pathophysiology, neurological manifestations, and neuroscience provider recommendations and guidelines. RESULTS: Central nervous system manifestations range from vague nonfocal complaints to severe neurological impairment associated with encephalitis. It is unclear whether the neurological dysfunction results from direct viral injury or systemic disease. The virus could affect brainstem pathways that lead to indirect respiratory dysfunction, in addition to direct pulmonary injury. Necessary adaptations in patient management, triage, and diagnosis are evolving in light of the ongoing scientific and clinical findings. CONCLUSIONS: The present review has consolidated the current body of data regarding the neurological impact of coronaviruses, discussed the reported neurological manifestations of COVID-19, and highlighted the recommendations for patient management. Specific recommendations pertaining to clinical practice for neurologists and neurosurgeons have also been provided.