关键词： Analytical methods   Dopamine   Plasma   Neurological disorders  

摘要： Since dopamine (DA) was discovered as an essential neurotransmitter, with a profound impact on motor control, memory, and behavioral impulses, the pathogenesis of several neurodegenerative and neuropsychiatric disorders have been associated with the dysfunction of the dopaminergic system. Regarding this, the most common drugs used to treat these pathologies act on the dopaminergic neurons. Therefore, the measurement of DA and its precursors and metabolites levels can be a useful tool to help the diagnosis and development of targeted therapeutic approaches to neurological disorders. Furthermore, monitoring and detecting DA metabolism (DA, precursors, and metabolites) in biological samples, like plasma, urine, and cerebrospinal fluid, constitute an interesting subject from a clinical perspective. However, the development of suitable and efficient methods to determine these compounds in biological samples remains a challenge. Thus, this review provides an overview of the recent advances and available methodologies to quantify DA and its precursors and metabolites in plasma samples focusing on previous reports which used less than two milliliters. Also, it deals with the actual extraction and separation techniques, as well as detection modes;and it gives a perspective, on the present-day, about the use of analytical methods as a helpful tool to improve diagnosis. (C) 2020 Elsevier B.V. All rights reserved.

关键词： 神经病学   CBL教学法   PBL教学法   RPT教学法   见习教学  

摘要： 目的探索CBL+PBL+RPT教学法应用于MBBS留学生神经病学见习教学的效果。方法以昆明医科大学2015级MBBS留学生为研究对象,试验组27人采用CBL+PBL+RPT教学法,对照组27人采用传统见习教学法。使用Mini-CEX临床技能评价量表评价两组学生的见习效果。结果试验组病史询问、临床判断、组织效能和整体表现评分均高于对照组,差异具有统计学意义(P<0.05)。结论CBL+PBL+RPT教学法可明显提高MBBS留学生神经病学见习效果,值得推广。

关键词： education   teleneurology   telehealth   telemedicine  

摘要： Background:With increasing demand for neurologists, nontraditional health care delivery mechanisms have been developed to leverage this limited resource. Introduction:Telemedicine has emerged as an effective digital solution. Over the past three decades, telemedicine use has steadily grown;however, neurologists often learn on the job, rather than as part of their medical training. The current literature regarding telestroke training during neurology training is sparse, focusing on cerebrovascular fellowship curricula. We sought to enhance telestroke training in our neurology residency by incorporating real-life application. Materials and Methods:We implemented a formal educational model for neurology residents to use telemedicine for remote acquisition of the National Institutes of Health Stroke Scale (NIHSS) for patients with suspected acute ischemic stroke (AIS) before arrival at our comprehensive stroke center. This three-phase educational model involved multidisciplinary classroom didactics, simulation exercises, and real-world experience. Training and feedback were provided by neurologists experienced in telemedicine. Results:All residents completed formal training in telemedicine prehospital NIHSS acquisition and had the opportunity to participate in additional simulation exercises. Currently, residents are gaining additional experience by performing prehospital NIHSS acquisition for patients in whom AIS is suspected. Our preliminary data indicate that resident video encounters average 10.6 min in duration, thus saving time once patients arrive at our hospital. Discussion:To our knowledge, this is the first report of a telestroke-integrated neurology residency program in a comprehensive stroke center resulting in shortened time to treatment in patients with suspected AIS. Conclusions:We present a model that can be adopted by other neurology residency programs as it provides real-world telemedicine training critical to future neurologists.

关键词： intracerebral hemorrhage   arundic acid (ONO-2506)   astrocyte   S100B   neuroprotection  

摘要： Stroke is one of the leading causes of mortality and neurological morbidity. Intracerebral hemorrhage (ICH) has the poorest prognosis among all stroke subtypes and no treatment has been effective in improving outcomes. Following ICH, the observed high levels of S100B protein have been associated with worsening of injury and neurological deficits. Arundic acid (AA) exerts neuroprotective effects through inhibition of astrocytic synthesis of S100B in some models of experimental brain injury;however, it has not been studied in ICH. The aim of this study was to evaluate the effects of intracerebroventricular (ICV) administration of AA in male Wistar rats submitted to ICH model assessing the following variables: reactive astrogliosis, S100B levels, antioxidant defenses, cell death, lesion extension and neurological function. Firstly, AA was injected at different doses (0.02, 0.2, 2 and 20 mu g/mu l) in the left lateral ventricle in order to observe which dose would decrease GFAP and S100B striatal levels in non-injured rats. Following determination of the effective dose, ICH damage was induced by IV-S collagenase intrastrial injection and 2 mu g/mu l AA was injected through ICV route immediately before injury. AA treatment prevented ICH-induced neurological deficits and tissue damage, inhibited excessive astrocytic activation and cellular apoptosis, reduced peripheral and central S100B levels (in striatum, serum and cerebrospinal fluid), improved neuronal survival and enhanced the antioxidant defences after injury. Altogether, these results suggest that S100B is a viable target for treating ICH and highlight AA as an interesting strategy for improving neurological outcome after experimental brain hemorrhage. (C) 2020 IBRO. Published by Elsevier Ltd. All rights reserved.

关键词： 临床神经病学   微信公众平台   信息反馈   微信号   三种方式   杂志  

摘要： 为了加强与广大读者、作者以及专家的沟通,及时进行信息反馈,《临床神经病学杂志》微信公众平台于2015年8月正式开通,欢迎大家关注!您可通过以下三种方式关注《临床神经病学杂志》微信公众平台:1、搜索公众订阅号名称"临床神经病学杂志"添加关注;2、搜索微信号"lcsjbx"添加关注;3、扫描位于本刊目次页右上角的微信二维码。

关键词： 神经病学   MOOC   CBL   腰椎穿刺术  

摘要： 目的:探讨MOOC联合CBL教学法在神经病学临床教学中的效果。方法:60名本科生随机分为实验组和对照组。实验组采用MOOC联合CBL教学法,对照组采用传统教学法。应用问卷调查和考试成绩评价教学效果。结果:实验组好评率和总成绩均高于对照组(P<0.05)。结论:MOOC联合CBL教学法能够提高学生的学习热情和思考能力,提高神经病学的教学质量。

关键词： 神经内科   硕士生导师   特色专科   神经病学   出院病人   防治中心   医疗组   科室  

摘要： 贵州医科大学附属医院神经内科成立于1956年,由我省著名神经病学专家卢亮教授创建。经过半个多世纪的发展,目前我科室已拥有4个病区,5个医疗组,共有病床120张,成为集医疗、教学、科研为一体的特色专科。现年出院病人近4000余人。门诊年平均接诊病人35000余人次。科室有医护技人员85人,其中具有高级职称20人,博士5人,硕士17人,硕士生导师9人。

关键词： 病例讨论   医学专业   神经病学   学术交流平台   编辑部编辑   有奖征文启事   癫痫   学术期刊  

摘要： 癫痫是神经病学临床工作的热点、难点之一,作为癫痫学科学术交流平台的《癫痫杂志》于2015年7月创刊。《癫痫杂志》是由教育部主管,四川大学主办,《癫痫杂志》编辑部编辑出版的医学专业类学术期刊,系中国抗癫痫协会会刊。本刊分为论著、综述、Epilepsia专栏、病例讨论、世界舞台.中国好声音、纪要等栏目。为了更好地促进我国癫痫专业领域的科研进展,提高我国癫痫诊疗的规范化程度和学术水平,现特举办有奖征文活动。现将相关事项说明如下。

关键词： 来源期刊   神经免疫学   科研成果   科研人员   中国学术期刊   中国免疫学会   神经病学   学术性期刊  

摘要： 《中国神经免疫学和神经病学杂志》是全国惟一与神经免疫学相关的神经病学学术性期刊,由卫健委主管,北京医院、中国免疫学会神经免疫分会主办,国内外公开发行。本刊以从事神经免疫学和神经病学临床和科研人员等为主要读者对象,报道神经疾病领域尤其是神经免疫学领域的科研成果。本刊属中国科技论文统计源期刊、中国科技核心期刊、中国科技引文数据库来源期刊与中国学术期刊综合评价数据库来源期刊等。

关键词： 省级重点学科   右江民族医学院   神经病学   附属医院   临床医学院   学科创建   交界区   优势特色学科  

摘要： 神经病学学科创建于1988年,经过30多年建设,目前已发展成为具有4个病区、150张开放床位、师资队伍强大、技术力量雄厚,在桂滇黔三省交界区具有较大影响力的优势特色学科,是省级重点学科、省级医药卫生重点学科和省级临床重点专科。