关键词： 医院神经科   药物临床试验机构   诊疗中心   南京中医药大学   神经病学   脑死亡   评估中心   南京大学医学院  

摘要： 一、南京大学医学院附属鼓楼医院神经科简介南京大学医学院附属鼓楼医院神经科为江苏省神经病学重点学科、江苏省临床重点专科、江苏省脑血管病诊疗中心、江苏省卫生健康委员会脑卒中救治联盟牵头单位等,国家药物临床试验机构、国家卫生部住院医师规范化培训基地、国家神经内科住院医师规范化培训骨干师资培训基地、国家级继续教育基地、国家卫生健康委员会示范高级卒中中心、国家卫生健康委员会脑卒中筛查与防治基地、国家示范脑卒中中心、国家卫生健康委员会静脉溶栓培训基地、国家卫生健康委员会脑死亡评估中心、江苏省脑卒中中心等,南京市神经病学医学中心、南京市神经病学转化医学中心。南京大学、南京医科大学、南京中医药大学、东南大学、江苏大学以及徐州医科大学硕士和博士研究生培养基地,博士后流动工作站。

关键词： 病例报告   投稿要求   撰稿要求   前沿性   结构严谨  

摘要： 1.来稿应具科学性、前沿性、逻辑性和实用性,要求资料真实、数据可靠、论点鲜明、结构严谨、文通字顺。论著、综述等一般不超过5000字(包括图表和参考文献),经验类文稿、短篇及病例报告等不超过2000字。具体撰稿要求可参见我刊官网(***)的稿约。

关键词： 神经内科   硕士生导师   特色专科   神经病学   出院病人   防治中心   医疗组   科室  

摘要： 贵州医科大学附属医院神经内科成立于1956年,由我省著名神经病学专家卢亮教授创建。经过半个多世纪的发展,目前我科室已拥有4个病区,5个医疗组,共有病床120张,成为集医疗、教学、科研为一体的特色专科。现年出院病人近4000余人。门诊年平均接诊病人35000余人次。科室有医护技人员85人,其中具有高级职称20人,博士5人,硕士17人,硕士生导师9人。

关键词： 北京大学出版社   核心期刊表   文献计量学   《中文核心期刊要目总览》   《中国图书馆分类法》   神经病学   精神病学   专家评审  

摘要： 《中华老年心脑血管病杂志》主编:我们谨此郑重通知:依据文献计量学的原理和方法,经研究人员对相关文献的检索、统计和分析,以及学科专家评审,贵刊《中华老年心脑血管病杂志》入编《中文核心期刊要目总览》2017年版(即第8版)之“神经病学与精神病学”类的核心期刊。该书由北京大学出版社出版。书中按《中国图书馆分类法》的学科体系,列出了78个学科的核心期刊表,并逐一对核心期刊进行了著录。

关键词： Time series algorithm model   Neurology nursing work   Workload statistics   Information-assisted sensing system   Human resource allocation  

摘要： Objective: This paper studies the measurement indicators of nursing workload in neurology department, discusses the development and development law of nursing workload, provides scientific basis for nursing staff deployment, and guarantees high-quality and safe nursing services. Methods: By using time series algorithm model, the paper calculates the nursing workload of neurology department and establishes the measurement index of nursing workload of neurology department. Improve the nursing workload information system, automatically generate and extract daily nursing workload, and construct a time series model of daily nursing workload. Results: Through literature search and on-site observation, preliminary measurement of nursing workload measurement indicators, consultation with expert meetings to develop an expert consultation form for nursing workload measurement indicators, and application of SPSS 19.0 for time series analysis to construct a time series model for daily nursing workload. Results: The best fit models of the time series of the two wards in neurology department were both exponential smoothing models. The predictive value of the ward A smoothing model for the total nursing workload from January 1 to 3, 2014 was 317.39. 316.14, 295.94 points (upper limit: 366.39, 375.95, 364.88 points;lower limit: 268.40, 256.33, 227.00 points). The prediction value of the B Ward Index Smoothing Model for the total nursing workload from January 1 to 3, 2014 is 450.03, 449.38, 445.58 points (upper limit: 503.76, 512.04, 515.05 points;lower limit: 396.30, 386.71, 375.11 points). Conclusion: Time series analysis can predict the nursing workload on the one hand, and adjust the number of nurses on the day of work according to the short-term predicted value of the nursing workload on the time series model;on the other hand, it can evaluate the rationality of the existing manpower allocation strategy. (C) 2020 Elsevier Ltd. All rights reserved.

关键词： epilepsy   autism   protein kinase   inhibitory synapses   neurodegeneration  

摘要： Two major processes tightly regulate protein synthesis, the initiation of mRNA translation and elongation phase that mediates the movement of ribosomes along the mRNA. The elongation phase is a high energy-consuming process, and is mainly regulated by the eukaryotic elongation factor 2 kinase (eEF2K) activity that phosphorylates and inhibits eEF2, the only known substrate of the kinase. eEF2K activity is closely regulated by several signaling pathways because the translation elongation phase strongly influences the cellular energy demand and can change the expression of specific proteins in different tissues. An increasing number of recent findings link eEF2k over activation to an array of human diseases, such as atherosclerosis, pulmonary arterial hypertension, progression of solid tumors, and some major neurological disorders. Several neurological studies suggest that eEF2K is a valuable target in treating epilepsy, depression and major neurodegenerative diseases. Despite eEF2k is an ubiquitous and conserved protein, it has been proved that its deletion does not affect development in animal models and in general cell viability. Therefore, it is possible to postulate that inhibiting its function may not cause serious side effects. In addition, eEF2K is a peculiar kinase molecularly different from most of other mammalian kinases and new compounds that inhibit eEF2K should not necessarily interfere with other important protein kinases. In this review we will critically summarize the evidence supporting the role of the altered eEF2K/eEF2 pathway in defined neurological diseases and its implications in curing these diseases in animal models, and possibly in humans, by targeting eEF2K activity. This article is part of a Special Issue entitled: Animal Models of Neurodevelopmental Disorders. (C) 2020 IBRO. Published by Elsevier Ltd. All rights reserved.

关键词： 办刊宗旨   中国医师协会   神经疾病   神经解剖学   普及与提高   神经病学   专业期刊   神经内外科  

摘要： 《中国现代神经疾病杂志》为国家卫生健康委员会主管、中国医师协会主办的神经病学类专业期刊。办刊宗旨为:理论与实践相结合、普及与提高相结合,充分反映我国神经内外科临床科研工作重大进展,促进国内外学术交流。所设栏目包括述评、专论、论著、临床病理报告、应用神经解剖学、神经影像学、循证神经病学、流行病学调查研究、基础研究、临床研究、综述、临床医学图像、病例报告、临床病理(例)讨论、新技术新方法等。

关键词： neurological assessment   neurological symptoms   prognostic factors in brain metastases   survival prognosis in symptomatic brain metastases   symptomatic burden  

摘要： Background Brain metastases (BM) are a frequent complication of advanced cancer and are characterized by a variety of neurological symptoms. Although the presence of neurological symptoms is included in the response assessment in patients with primary brain tumors, to the authors' knowledge little is known regarding the prognostic impact of neurological symptoms in patients with BM. Methods Patients with newly diagnosed BM from non-small cell lung cancer were identified from the Vienna Brain Metastasis Registry and were evaluated according to the incidence, distribution, and prognostic impact of neurological symptoms at the time of diagnosis of BM. Results A total of 1608 patients (57.3% male and 42.7% female;median age, 62 years) were available for further analyses. Neurological symptoms including focal deficits (985 patients;61.3%), signs of increased intracranial pressure (483 patients;30.0%), epileptic seizures (224 patients;13.9%), and neuropsychological symptoms (233 patients;14.5%) were documented in 1186 of the 1608 patients (73.8%). Patients with asymptomatic BM presented with a longer median overall survival after the diagnosis of BM compared with patients with symptomatic BM (11 months vs 7 months;P < .001). In multivariate analysis with a diagnosis-specific graded prognostic assessment (hazard ratio, 1.41;95% CI, 1.33-1.50 [P < .001]), the presence of neurological symptoms (hazard ratio, 1.39;95% CI, 1.23-1.57 [P < .001]) was found to be independently associated with survival prognosis from the time of diagnosis of BM. Conclusions Neurological symptoms at the time of BM diagnosis demonstrated a strong and independent association with survival prognosis. The results of the current study have highlighted the need for the integration of the presence of neurological symptoms into the prognostic assessment of patients with BM from non-small cell lung cancer. Lay Summary Neurological symptom evaluation is included regularly in the assessment of patients with p

关键词： 办刊宗旨   学术刊物   临床神经病学   读者对象   中级人员   神经科医师   五官科   注重实用  

摘要： 《临床神经病学杂志》系国家级神经病学专业性学术刊物,由南京医科大学附属脑科医院主办。刊登内容以临床神经病学为主,兼及有关边缘学科。读者对象以从事临床神经病学专业的高、中级人员为主,也可供内科、儿科、眼科、五官科医师参阅。本刊的办刊宗旨是:面向临床,面向基层,注重实用,鼎力于提高我国临床神经科医师的专业理论及诊疗水平。