关键词： IoT   eHealth   wearable technology   eye blink   glasses   neurological diseases   signal processing  

摘要： The leading trends in the framework of the Internet of Things are driving the research community to provide smart systems and solutions aimed at revolutionizing medical sciences and healthcare. One of the major opportunities offered by IoT lies in the ubiquitous connectivity, thus enabling smart services such as remote patient monitoring, in-home therapy/rehabilitation, and assisted living platforms. In this paper we present a prototype of wearable smart glasses able to monitor the Eye Blinks (EBs) through ElectroOculoGram (EOG) signal in a transparent way with respect to the final user. We propose a novel pre-filtering scheme to reduce EOG noise along with an analytical derivation of a matched filter to detect and count EBs. We have carried out an in-depth experimental campaign in order to validate the robustness of our approach with respect to the main solutions available in the literature. Furthermore, we have compared the performances obtained with out wearable prototype versus the results achievable with professional medical equipments. Results show that our solution is able to achieve very high accuracy in EB detection, obtaining comparable performance with respect to professional medical desktop equipment, with the additional benefit of portability, comfort and easiness of use for the patients.

关键词： Cytokine storm   COVID-19   Neurological complications   Coronavirus   Hypercytokinemia   Encephalopathy   Interferons   Cerebrovascular disease   Skeletal muscle injury   Guillain-Barre Syndrome  

摘要： The new coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), can trigger a hyperinflammatory state characterized by elevated cytokine levels known as hypercytokinemia or cytokine storm, observed most often in severe patients. Though COVID-19 is known to be a primarily respiratory disease, neurological complications affecting both the central and peripheral nervous systems have also been reported. This review discusses potential routes of SARS-CoV-2 neuroinvasion and pathogenesis, summarizes reported neurological sequelae of COVID-19, and examines how aberrant cytokine levels may precipitate these complications. Clarification of the pathogenic mechanisms of SARS-CoV-2 is needed to encourage prompt diagnosis and optimized care. In particular, identifying the presence of cytokine storm in patients with neurological COVID-19 manifestations will facilitate avenues for treatment. Future investigations into aberrant cytokine levels in COVID-19 patients with neurological symptoms as well as the efficacy of cytokine storm-targeting treatments will be critical in elucidating the pathogenic mechanisms and effective treatments of COVID-19.

关键词： neural stem cell homeostasis   Wnt/beta-catenin signaling   neurological diseases   spinal cord injury   depression   Alzheimer's disease   Parkinson's disease  

摘要： Neural stem/progenitor cells (NSCs) maintain the ability of self-renewal and differentiation and compose the complex nervous system. Wnt signaling is thought to control the balance of NSC proliferation and differentiation via the transcriptional coactivator beta-catenin during brain development and adult tissue homeostasis. Disruption of Wnt signaling may result in developmental defects and neurological diseases. Here, we summarize recent findings of the roles of Wnt/beta-catenin signaling components in NSC homeostasis for the regulation of functional brain circuits. We also suggest that the potential role of Wnt/beta-catenin signaling might lead to new therapeutic strategies for neurological diseases, including, but not limited to, spinal cord injury, Alzheimer's disease, Parkinson's disease, and depression.

关键词： COVID-19   Neurology   Acute respiratory failure   Critically ill patients   Acute neurological involvement   Rehabilitation  

摘要： Novel coronavirus spread rapidly around the world infecting millions of people. It was thus declared a pandemic. This new virus damages the lungs. In the most severe cases, it leads to acute respiratory failure that requires intensive care treatment. However, many clinical reports have listed different neurological symptoms, leading to increased interest in the neurological involvement of COVID-19. Various pathophysiological mechanisms have been proposed to explain these neurological aspects. Direct viral invasion of the nervous system, systemic cytokine storm and severe hypoxemia are key factors in the development of symptoms. Critically ill patients present several additional risk factors for nervous system damage. Reasons for these include deep sedation and extended muscular paralysis, bed rest for several days, and the inability to receive proper physical rehabilitation. After ICU treatment, COVID-19 patients generally require an extensive rehabilitation program. However, distancing restrictions mean that in many cases physiotherapists are unable to enter ICUs, delaying the process of rehabilitation. The role of telemedicine should be considered as an adjunctive tool in the rehabilitation of critically ill COVID-19 patients. (C) 2020 Elsevier Ltd. All rights reserved.

关键词： brain tumour   brain metastasis   complications   oedema   seizures   thrombosis  

关键词： CAMTA1   cerebellar dysfunction   clinical variation   developmental delay   genotype‐   phenotype correlations   intellectual disability   mutation spectrum   whole exome sequencing  

摘要： The CAMTA1-associated phenotype was initially defined in patients with intragenic deletions and duplications who showed nonprogressive congenital ataxia, with or without intellectual disability. Here, we describe 10 individuals with CAMTA1 variants: nine previously unreported (likely) pathogenic variants comprising one missense, four frameshift and four nonsense variants, and one missense variant of unknown significance. Six patients were diagnosed following whole exome sequencing and four individuals with exome-based targeted panel analysis. Most of them present with developmental delay, manifesting in speech and motor delay. Other frequent findings are hypotonia, cognitive impairment, cerebellar dysfunction, oculomotor abnormalities, and behavioral problems. Feeding problems occur more frequently than previously observed. In addition, we present a systematic review of 19 previously published individuals with causal variants, including copy number, truncating, and missense variants. We note a tendency of more severe cognitive impairment and recurrent dysmorphic features in individuals with a copy number variant. Pathogenic variants are predominantly observed in and near the N- and C- terminal functional domains. Clinical heterogeneity is observed, but 3 '-terminal variants seem to associate with less pronounced cerebellar dysfunction.

关键词： COVID-19 infection   Parkinson's disease   Alzheimer's disease   Multiple sclerosis  

摘要： Neurological disorders and coronavirus 2019 (COVID-19) pandemic are two conditions with a recent well-documented association. Intriguing evidences showed that COVID-19 infection can modify clinical spectrum of manifested neurological disorders but also it plays a crucial role in the development of future diseases as long-tem consequences. In this viewpoint review, we aimed to assess the vulnerability to SARS-CoV-2 infection and development of COVID-19 among neurological disorders. With this in mind, we tested the hypothesis that age rather than neuropathology itself could be decisive in neurodegenerative diseases such as Parkinson's disease, whereas neuropathology rather than age may be critical in neuroimmunological diseases such as Multiple Sclerosis. Highlighting the role of potential susceptibility or protection factors from this disastrous infection, we also stratify the risk for future neurodegeneration.