关键词： 编辑出版工作   临床神经病学   新一届编委会   期刊   献计献策   杂志   第七届   委员会  

摘要： 截至2018年底,《临床神经病学杂志》第六届编辑委员会的任期已经届满。为更好地促进期刊的发展,《临床神经病学杂志》成立了第七届编辑委员会。期待新一届编委会能够继续帮助和支持编辑部的工作,为本刊献计献策。自《临床神经病学杂志》第六届编辑委员会成立以来,编委会全体成员对《临床神经病学杂志》的编辑出版工作作出了极大的贡献。

关键词： 神经系统疾病   神经病学   评审委员会   基础应用研究   健康促进   创新基金项目   中标   (中国)  

摘要： 为进一步推动我国神经病学临床与基础应用研究,提高神经系统疾病诊断和治疗水平,造福广大神经系统疾病患者,由中国健康促进基金会发起、卫材(中国)药业有限公司捐助的神经病学青年创新基金项目于2020年6月正式启动,经过评审委员会专家们网上初评和现场终评,从50多份标书中评选出2020年10个中标课题。

关键词： 神经内科疾病   神经系统疾病   内科系统   病情变化   诊断思路   神经病学   住院医师规范化培训   脑血管病  

摘要： 随着人口的老龄化的增加,脑血管病、帕金森病、痴呆等神经内科疾病日益增多。神经病学,是内科系统最难学的学科,强调定位及定性诊断,与内科疾病诊断思路与不同,既抽象又复杂。医学对神经系统疾病的认识相对局限,且因神经系统疾病的致残、致死率高,病情变化快,且治疗手段有限等特点增加了临床诊治及沟通的难度。

关键词： 中国工商银行   北京医院   版面费   银行转账   投稿系统   开户名  

摘要： 最近一段时间,有作者在向我刊投稿时,由于未能正确识别我刊官方投稿系统,导致投稿失败,甚至发生经济损失的情形。在此提醒广大的作者朋友们注意:(1)投稿途径:除特殊情况外,我刊目前仅处理从我刊官方系统所接收的来稿,不再处理通过邮寄纸质以及来自Email、QQ等途径的投稿。请作者投稿前确认我刊网址(http://***/),进行网上投稿,首次投稿的作者请先进行注册后进行投稿。(2)关于费用:我刊不收取审稿费。凡经我刊评审通过录用的稿件,将收取一定版面费,收款惟一方式为银行转账汇款,转账汇款的开户名为:北京医院;开户银行为:中国工商银行北京市王府井金街支行;帐号:0200000709089135235。我刊不会要求作者以任何途径向个人汇款。

关键词： COVID-19   ACE2   Vascular   Brain   Angiotensin   Cytokine  

摘要： There is increasing evidence of neurological manifestations and complications in patients with coronavirus disease 19 (COVID-19). More than one-quarter of patients with COVID-19 developed various neurological symptoms, ranging from headache and dizziness to more serious medical conditions, such as seizures and stroke. The recent investigations introduced hyposmia as a potential early criterion of infection with COVID-19. Despite the high mortality and morbidity rate of COVID-19, its exact mechanism of action and pathogenesis is not well characterized. The spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) could interact with angiotensin-converting enzyme 2 (ACE2) in the endothelial, neural, and glial cells. In the present study, we reviewed the most common neurological manifestations and complications that emerged after infection with the SARS-CoV-2 and discussed their possible relation to the expression and function of ACE2. Comprehensive and detailed studies are required to uncover how this virus invades the neural system as well as other critical organs.

关键词： Non-aneurysmal subarachnoid hemorrhage   Modified Fisher Scale   Vasospasm   Hydrocephalus  

摘要： Purpose Non-aneurysmal subarachnoid hemorrhage (NA-SAH) is a clinical-radiological entity with a different prognosis than aneurysmal SAH (A-SAH). The purpose of this study is to assess the predictive value of the modified Fisher Scale (mFS) for neurological complications in patients with this diagnosis. Methods We recruited patients admitted at our hospital services between 2009 and 2017 who were diagnosed with spontaneous SAH, with either perimesencephalic (PM-SAH) or diffuse pattern (D-SAH), an initial negative angio-CT, and at least one digital subtraction angiography of brain vessels discarding underlying brain aneurysms or other vascular malformations. Results The retrospective observational study included 116 patients. The mean age was 54.4, and the sample included predominantly male subjects (62.9%). Hunt and Hess (HH) scores on admission ranged from 3 to 5 in 18.1% of patients. The prevalence of hydrocephalus requiring ventricular drainage was 18.1%. The prevalence of symptomatic vasospasm was 4.3%. A modified Rankin Scale (mRS) 0-2 at discharge was found in 95.6%. In a multivariate logistic regression for the presence of neurological complications including age, sex, admission HH 3-5 compared with < 3, mFS 4 compared with mFS < 4, D-SAH compared with PM-SAH, and mRS score at discharge of 0-2 compared with > 2, the only significant predictors were mFS 4 compared with mFS < 4 (OR 4.47 (95% CI 1.21, 16.66)pvalue = 0.03) and D-SAH compared with PM-SAH (OR 7.10 (95% CI 1.24, 40.8)pvalue = 0.03). Conclusion In patients with NA-SAH, a mFS score of 4 and/or a D-SAH bleeding pattern in non-contrast cranial CT on admission predicted the development of relevant neurological complications.

关键词： Cochlear implantation   MRI safety   magnet removal   artefact   neurological disease  

摘要： Cochlear implant (CI) is a reliable solution to restore hearing in people with severe-to-profound hearing loss. The device is made up of internal and external components linked transcutaneously through a magnet that may rise specific issues in people who must undergo brain magnetic resonance (MRI) due to neurological diseases. The description of a case of a CI implantee needing MRI has given us the opportunity to highlight the differences that can be encountered among different neuropathies, either acute or chronic, with the aim of shedding some light for finding a common protocol when facing this important and frequent clinical issue. In particular, the removal of the magnet prior to performing an MRI exam is mandatory for brain diseases ipsilateral to the implanted side, whereas for contralateral side lesions it is less important when using apposite bandage kits. Laryngoscope, 2020

关键词： neurological diseases   pediatric   TPE  

摘要： Therapeutic plasma exchange is used to treat neurological diseases in the pediatric population. Since its first use in pediatric patients with hepatic coma in the form of manual whole blood exchange, therapeutic plasma exchange has been increasingly used to treat these disorders of the nervous system. This expansion is a result of improved techniques and apheresis instruments suitable for small children, as well as the recognition of its applicability to many diseases in the pediatric population. This review provides a historical overview of the use of therapeutic apheresis in children and highlights the most common applications for therapeutic plasma exchange to treat neurological disorders in children.

关键词： Pesticides mixtures   Long-term exposure   Low dose exposure   Oxidative stress   Neurotoxicity  

摘要： Humans are usually exposed to multiple pesticides in real life, but little is known as yet about the safety of low-dose pesticides mixtures. This study was conducted to evaluate the effects of long-term exposure to very low doses of pesticide mixtures on biochemical, histological, and neurobehavioral alterations in the rat model. For 90 days, four groups of male Wistar rats were given a mixture of five pesticides (in drinking water) in doses of 0, 0.25, 1 and 5 times the legally permitted levels (mg/kg body weight/day). After three-month exposure, the neurobehavioral effects of pesticide mixtures were evaluated by the Morris water maze, elevated plus maze and the open field tests. Then the biochemical and histopathological alterations in the hippocampus of studied animals were evaluated. Results showed that long-term exposure to a combination of five pesticides affected the nervous system in dose-dependent manner. As expected, nearly all of the parameters determined in this study were adversely changed in the high dose group. Exposure to medium dose (permitted level of pesticides mixture) was also able to induce oxidative stress and impaired memory and learning ability, although not all parameters were significantly changed in this group. It means that pesticides may behave differently when mixed. Interestingly, the administration of low doses of these chemicals induced an adaptive response by stimulating the redox system. In conclusion, it seems that the prolonged exposure to pesticide mixtures may cause adverse neurobehavioral effects, even at permitted levels. (C) 2020 Elsevier Ltd. All rights reserved.