关键词： Dexmedetomidine   Neonatal hypoxic ischemia   Autophagy  

摘要： Background: Hypoxic-ischemic brain injury (HIBI) is a major cause of mortality in neonates and can cause long-term neurological sequelae. Excessive autophagy caused by HI may cause neuronal death. Dexmedetomidine was reported neuroprotective against HIBI. Therefore, in the present study, the autophagy-related mechanisms underlying the protective effects of dexmedetomidine against cerebral HI in neonatal rats were investigated. Methods: In the present study, the expression of autophagy-related proteins microtubule-associated protein 1 light chain 3 (LC3) B-II and Beclin1, neuronal and microglia autophagy levels, the myelin basic protein (MBP) expression, long-term neuronal density ratio, and long-term behavioral prognosis in HIBI model were investigated by ligating the left common carotid artery in neonatal rats, followed by 2-h hypoxia. Results: Dexmedetomidine inhibited the overactivated autophagy of hippocampal neurons and microglia after HI. In addition, dexmedetomidine inhibited neuronal density decrease and axon demyelination after HI-induced overactivated autophagy. Lastly, dexmedetomidine improved the long-term neurological prognosis and was reversed by the autophagy agonist rapamycin. Conclusion: The protective effects of dexmedetomidine on HI neonatal rats were evidenced by inhibition of excessive autophagy of neurons and microglia, thereby reducing the decline of long-term neuronal density and axon demyelination as well as improving long-term learning cognitive function.

关键词： 行为导向教学法   多媒体教学   神经病学   规培医师   住院医师规范化培训  

摘要： 目的探讨行为导向教学法联合多媒体教学在住院医师规范化培训神经内科教学中的应用效果。方法选取2018年9月1日至2019年9月1日在南京医科大学附属江宁医院进行住院医师规范化培训并在神经内科轮转的医师50名,随机分为实验组(25名)和对照组(25名),分别应用行为导向教学法和传统授课教学法,并均应用多媒体技术完成神经病学教学任务,轮转结束后采用问卷调查和出科考试两种方法评估教学效果。结果问卷调查显示实验组在理论知识掌握、学习兴趣、分析解决问题能力、语言表达能力、创新思维能力等方面的培养均显著优于对照组(P<0.05),前者的出科考试成绩亦显著高于后者,差异具有统计学意义(P<0.05)。结论行为导向教学法联合多媒体教学可激发规培医师的学习兴趣和自主学习能力,提高考试成绩,提升临床神经病学的教学效果。

关键词： 办刊宗旨   学术刊物   临床神经病学   读者对象   中级人员   学术交流   病例报告   问题解答  

摘要： 《临床神经病学杂志》系国家级神经病学专业性学术刊物,由南京医科大学附属脑科医院主办。刊登内容以临床神经病学为主,兼及有关边缘学科。读者对象以从事临床神经病学专业的高、中级人员为主,也可供内科、儿科、眼科、五官科医师参阅。本刊的办刊宗旨是:面向临床,面向基层,注重实用,鼎力于提高我国临床神经科医师的专业理论及诊疗水平。一、本刊设有专家论坛、述评、论著、学术交流、专题笔谈、综述、讲座、临床病理(例)讨论、教学园地、问题解答、临床研究、病例报告、误诊误治、技术改进等栏目,接受全国各地来稿。

关键词： 办公系统   在线注册   登录系统   邮件主题   网址   纸质材料   确认书   网站首页  

摘要： 1.请打开本刊网址(http: //***),点击"投稿及审稿办公系统",进行在线注册。2.注册后登录系统,并以第一作者的中文姓名在线提交稿件(请勿以通讯作者或姓名拼音提交稿件)。3.在网站首页下载中心下载《版权转让确认书》,签字并加盖公章后拍照或扫描成电子版发至2105933141@***, 并在邮件主题中注明"第一作者姓名"及"投稿"字样,如"张三-投稿"。4.不需要邮寄纸质材料。

关键词： 流行病学专家   小齿轮   病耻感   神经病学   癫痫病   抗癫痫   污名化  

摘要： “很多人都问过我同样的问题,如何看待癫痫这种疾病?我的回答永远是:没有人比患者更了解癫痫,而我们永远在外围。”作为国际癫痫病友会(IBE)副主席、中国抗癫痫协会(CAAE)副秘书长、复旦大学附属华山医院神经病学研究所流行病学专家,丁玎教授却认为,对于癫痫自己依旧“知之甚少”。当癫痫病因依旧成谜,当污名化、病耻感正困扰患者,丁玎教授和她的同行们早已将目光从“病”转移到“人”的身上。面对癫痫疾病,丁玎教授期待,抗癫痫事业里每个人都是“小齿轮”。

关键词： conversion disorder   diffusion tensor imaging   dissociative seizures   DTI   functional movement disorder   interoception   psychogenic  

摘要： In motor functional neurological disorders (mFND), relationships between interoception (a construct of high theoretical relevance to its pathophysiology) and neuroanatomy have not been previously investigated. This study characterized white matter in mFND patients compared to healthy controls (HCs), and investigated associations between fiber bundle integrity and cardiac interoception. Voxel-based analysis and tractography quantified fractional anisotropy (FA) in 38 mFND patients compared to 38 HCs. Secondary analyses compared functional seizures (FND-seiz;n = 21) or functional movement disorders (n = 17) to HCs. Network lesion mapping identified gray matter origins of implicated fiber bundles. Within-group mFND analyses investigated relationships between FA, heartbeat tracking accuracy and interoceptive trait prediction error (discrepancies between interoceptive accuracy and self-reported bodily awareness). Results were corrected for multiple comparisons, and all findings were adjusted for depression and trait anxiety. mFND and HCs did not show any between-group interoceptive accuracy or FA differences. However, the FND-seiz subgroup compared to HCs showed decreased integrity in right-lateralized tracts: extreme capsule/inferior fronto-occipital fasciculus, arcuate fasciculus, inferior longitudinal fasciculus, and thalamic/striatum to occipital cortex projections. These alterations originated predominantly from the right temporoparietal junction and inferior temporal gyrus. In mFND patients, individual differences in interoceptive accuracy and interoceptive trait prediction error correlated with fiber bundle integrity originating from the insula, temporoparietal junction, putamen and thalamus among other regions. In this first study investigating brain-interoception relationships in mFND, individual differences in interoceptive accuracy and trait prediction error mapped onto multimodal integration-related fiber bundles. Right-lateralized limbic and associative trac

关键词： Subarachnoid hemorrhage   Ferroptosis   Inflammation   Liproxstatin-1  

摘要： Ferroptosis is a form of iron-dependent regulated cell *** of its existence and the effects of its inhibitors on subarachnoid hemorrhage(SAH)is still *** the present study,we found that liproxstatin-1 protected HT22 cells against hemin-induced injury by protecting mitochondrial functions and ameliorating lipid *** in vivo experiments,we demonstrated the presence of characteristic shrunken mitochondria in ipsilateral cortical neurons after ***,liproxstatin-1 attenuated the neurological deficits and brain edema,reduced neuronal cell death,and restored the redox equilibrium after *** inhibition of ferroptosis by liproxstatin-1 was associated with the preservation of glutathione peroxidase 4 and the downregulation of acylCoA synthetase long-chain family member 4 as well as cyclooxygenase *** addition,liproxstatin-1 decreased the activation of microglia and the release of IL-6,IL-1 b,and *** data enhance our understanding of cell death after SAH and shed light on future preclinical studies.

关键词： 神经病学   文化资本   慕课教育   传统教学   教育工作者   初步分析  

摘要： 神经病学知识复杂而抽象,传统的课堂教学效果不尽如人意。近年来国内外的教育实践表明,慕课具有为医学生和临床工作者提供自助式学习资料的优势,可以有效解决传统课堂教学模式的不足。文章以法国社会学家皮埃尔·布迪厄所提出的文化资本作为切入点,对神经病学慕课教育进行了初步分析,提出文化资本传承是神经病学慕课教育的重要内容和目的,神经病学教育工作者占有优势文化资本是神经病学慕课成功教学的根本和保障,但应避免因占有优势文化资本而对教学带来的负面作用。在此基础上,文章简要分析受教者进入神经病学慕课教育前占有文化资本差异的原因,进而据此提出此种差异对教育工作者的要求。