关键词： Kynurenine   Neurotransmitter   Pterin   LC-MS   MS   Urine  

摘要： Simultaneous determination of kynurenines, neurotransmitters, pterins and steroids linked to various neurological and metabolic diseases have important diagnostic significance for related pathology and drug monitoring. An improved, sensitive and selective ultra-high performance liquid chromatography coupled to electrospray ionization triple quadrupole mass spectrometric (UHPLC-MS/MS) method, based on our earlier publication, has been proposed for the quantitative measurement of 42 metabolites in human urine. The assay covers a larger number of analytes, uses an advanced, Waters Atlantis T3 chromatographic column and similarly meets the guideline of European Medicines Agency (EMA) on bioanalytical method validation. Analytical performance met all the EMA requirements and the assay covered the relevant clinical concentrations. Linear correlation coefficients were all > 0.998. Intra-day and inter-day accuracy and precision were 87-118%, 81-120% and 2-20%, respectively including the lower limit of quantification (LLOQ). The assay is expected to facilitate the diagnosis and allows drug level monitoring from urine.

关键词： 办刊宗旨   中国医师协会   神经疾病   神经解剖学   普及与提高   神经病学   专业期刊   神经内外科  

摘要： 《中国现代神经疾病杂志》为国家卫生健康委员会主管、中国医师协会主办的神经病学类专业期刊。办刊宗旨为:理论与实践相结合、普及与提高相结合,充分反映我国神经内外科临床科研工作重大进展,促进国内外学术交流。所设栏目包括述评、专论、论著、临床病理报告、应用神经解剖学、神经影像学、循证神经病学、流行病学调查研究、基础研究、临床研究、综述、临床医学图像、病例报告、临床病理(例)讨论、新技术新方法等。

摘要： Question. Different mobile EEG devices were shown to be technical usable and effective and therefore may also be used for EEG home-monitoring of neurological outpatients within their home environment. The HOME project intends to provide evidence of diagnostic and therapeutic yield of such an EEG home-monitoring. Besides the technical usability and feasibility, patients“ acceptability is a crucial aspect in design and implementation of EEG home-monitoring. The present study aims to examine factors influencing the acceptance in terms of behavioral intention to use a mobile dry-electrode EEG device for patient-controlled EEG home-monitoring. Methods. To measure (potential) patients“ acceptance of the EEG home-monitoring, we compiled a questionnaire based on the UTAUT model and additionally used the SF-36 to assess the participants” health status. The current routine care (e.g., monitoring in a hospital) serves as a comparison scenario and enables analyzes to be made as to which types of care are preferred by (potential) patients. We surveyed a sample of nearly 400 potential patients and 40 patients in Germany. For our analyses, we used partial least squares structural equation modeling to identify relevant factors determining the participants“ behavioral intention to use. Subgroup analyses allow comparisons of effects of different information provision formats (e.g., textual and/or visual information) and previous experiences. Results. The HOMETA study revealed the importance of information provision, in particular information regarding (1) the interaction possibilities between patient and physician, (2) the EEG device (e.g., technical properties, data transmission and security) used, and (3) the correct use of the EEG device. We found that the acceptance of the EEG home-monitoring is significantly influenced if it is also explained visually. Conclusions. In line with other studies, we confirm the applicability of the UTAUT model in the context of mobile health service

关键词： 柳叶刀   神经病学   脑卒中   新发脑梗死   防治形势   全球疾病负担研究   人口老龄化进程  

摘要： 脑卒中是我国成人致死、致残的首位原因,随着人口老龄化进程加快,脑卒中的防治形势更加严峻。2019年3月11日“柳叶刀”杂志的神经病学子刊发表的2016全球疾病负担研究一项分析显示,2016年全球1370万例新发脑梗死,中国占40%,为551万例;全球550万例因脑梗死亡,中国占1/3,为179万例。

关键词： Hepatitis C virus   Neurological disorders   Psychiatric disorders   Antiviral therapy   Quality of life   Hepatic encephalopathy  

摘要： Hepatitis C virus(HCV)infection is widespread and affects 71 million people *** hepatic manifestations are the most frequent,ranging from chronic hepatitis to cirrhosis and hepatocellular carcinoma,it is also associated with several extrahepatic *** patients may present nonspecific neurological symptoms,regardless of the presence of liver *** pathogenetic mechanisms underlying neurological symptoms have been hypothesized:neuroinvasion,immune-mediated damage,neurotransmitter alterations and *** of the central nervous system include cerebral vasculopathy,acute or subacute encephalopathy and inflammatory *** infection may be responsible for neuropathies,of which the most frequent form is symmetrical axonal sensory or sensory-motor polyneuropathy which causes loss of leg sensitivity and *** to 50%of patients with HCV infection may experience cognitive decline and psychological disorders,such as depression and *** associated neurocognitive disorder is independent of the presence of liver cirrhosis and affects different domains than in patients with hepatic *** can be studied using specific tests that mainly explore executive functions,verbal learning and verbal *** disorders significantly reduce the quality of *** new antiviral therapies improve the extrahepatic symptoms of HCV infection and their success depends on the achievement of sustained virological ***,the effect of therapy may differ depending on the type of organ involved;neurological symptoms can be irreversible if there is organic liver *** aim of this review is to provide a critical overview of physiopathological mechanisms,diagnostic and therapeutic strategies of the neurological and psychiatric effects of HCV infection.

关键词： 留学生   神经内科临床实习   标准化病人   规范化教学查房  

摘要： 目的探讨神经病学规范化教学查房联合以问题为基础的教学(problem-based learning,PBL)及标准化病人(standardized patients,SP)在留学生临床实习中的应用效果。方法选取2019年6月20日至2019年12月20日在哈尔滨医科大学附属二院神经内科临床实习的60名留学生作为研究对象,按照实习时间分为实验组和对照组,各30例。对照组应用传统教学查房方法问诊真实患者,实验组应用规范化教学查房联合PBL教学及SP进行学习。培训结束进行首次病程记录书写考核及问卷调查。采用SPSS 20.0统计软件进行t检验和卡方检验。结果实验组的病历书写成绩明显突出,差异有统计学意义(P<0.05)。实验组80%以上的留学生认同规范化教学查房联合PBL教学及SP模式,教学查房效果显著。结论针对留学生在神经内科临床实习中的教育,以规范化教学查房联合PBL教学及SP的教学查房方法效果显著。

关键词： 办公系统   在线注册   登录系统   邮件主题   网址   确认书   网站首页   在线提交  

摘要： 1.请打开本刊网址(http://***),点击"投稿及审稿办公系统",进行在线注册。2.注册后登录系统,并以第一作者的中文姓名在线提交稿件(请勿以通讯作者或姓名拼音提交稿件)。3.在网站首页下载中心下载《版权转让确认书》,签字并加盖公章后拍照或扫描成电子版发至2105933141@***,并在邮件主题中注明"第一作者姓名"及"投稿"字样,如"张三-投稿"。

关键词： 北京天坛医院   编制床位   神经肌肉病   运动障碍性疾病   日门诊量   重症医学科   神经病学   亚专科  

摘要： 一、首都医科大学附属北京天坛医院神经病学中心简介首都医科大学附属北京天坛医院神经病学中心为国家神经病学重点学科、国家临床重点专科。目前拥有编制床位300余张,日门诊量近1300人次,是全国规模最大、学科建设最齐全的神经病学学科之一。现设立“血管神经病学科”“神经重症医学科”“运动障碍性疾病科”“癫痫科”“神经感染与免疫疾病科”“神经肌肉病学科”“认知障碍性疾病科”及“头痛科”8个亚专科科室。

关键词： 审稿专家   审稿人   临床神经病学   编辑部   编委   杂志   保质保量  

摘要： 在2020年度,《临床神经病学杂志》得益于各位编委和审稿人的大力支持,保质保量地完成了审稿任务。本刊编辑部在此向以下各位审稿专家表示诚挚的谢意!

关键词： 编辑出版工作   神经病学   新一届编委会   先导力量   权威期刊   持续性   第七届  

摘要： 截至2018年底,《临床神经病学杂志》第六届编辑委员会的任期已经届满。为更好地促进期刊的发展,《临床神经病学杂志》成立了第七届编辑委员会。期待新一届编委会能够继续帮助和支持编辑部的工作,为本刊献计献策。自《临床神经病学杂志》第六届编辑委员会成立以来,编委会全体成员对《临床神经病学杂志》的编辑出版工作作出了极大的贡献。对此,我们表示衷心的感谢!相信在新一届的编辑委员会成员及编辑部的共同努力下,《临床神经病学杂志》能够成为我国神经病学领域的权威期刊,为推动神经病学的发展提供持续性的先导力量。