关键词： 北京天坛医院   编制床位   神经肌肉病   运动障碍性疾病   日门诊量   重症医学科   神经病学   亚专科  

摘要： 一、首都医科大学附属北京天坛医院神经病学中心简介首都医科大学附属北京天坛医院神经病学中心为国家神经病学重点学科、国家临床重点专科。目前拥有编制床位300余张,日门诊量近1300人次,是全国规模最大、学科建设最齐全的神经病学学科之一。现设立“血管神经病学科”“神经重症医学科”“运动障碍性疾病科”“癫痫科”“神经感染与免疫疾病科”“神经肌肉病学科”“认知障碍性疾病科”及“头痛科”8个亚专科科室。

关键词： 审稿专家   审稿人   临床神经病学   编辑部   编委   杂志   保质保量  

摘要： 在2020年度,《临床神经病学杂志》得益于各位编委和审稿人的大力支持,保质保量地完成了审稿任务。本刊编辑部在此向以下各位审稿专家表示诚挚的谢意!

关键词： 编辑出版工作   神经病学   新一届编委会   先导力量   权威期刊   持续性   第七届  

摘要： 截至2018年底,《临床神经病学杂志》第六届编辑委员会的任期已经届满。为更好地促进期刊的发展,《临床神经病学杂志》成立了第七届编辑委员会。期待新一届编委会能够继续帮助和支持编辑部的工作,为本刊献计献策。自《临床神经病学杂志》第六届编辑委员会成立以来,编委会全体成员对《临床神经病学杂志》的编辑出版工作作出了极大的贡献。对此,我们表示衷心的感谢!相信在新一届的编辑委员会成员及编辑部的共同努力下,《临床神经病学杂志》能够成为我国神经病学领域的权威期刊,为推动神经病学的发展提供持续性的先导力量。

关键词： 中华医学会   江苏省医学会   神经病学   学术活动   脑血管病   南京大学医学院   临床专家   鼓楼医院  

摘要： 由中华医学会、中华医学会神经病学分会主办,中华医学会神经病学分会脑血管病学组、江苏省医学会承办,南京大学医学院附属鼓楼医院、苏州大学附属第二医院协办的第21次中国脑血管病大会拟定于2021年11月18-20日在江苏省苏州市举行。届时将邀请国内著名脑血管病专家和神经病学临床专家进行专题讲座,并举办各种形式的学术活动。

关键词： Oropouche virus   Arbovirus   Central nervous system   Neurological disease   Neglected disease  

摘要： We describe two neurological cases of Oropouche virus infection in northern Brazil, where the virus is endemic but neglected as a pathogen. This study reiterates the necessity of developing protocols for diagnosing infections and training medical personnel to recognize the pathogenicity of Oropouche virus in neurological infections.

关键词： Nitrous oxide   Toxic   Vitamin B12 deficiency   Passive inhalation  

关键词： Sudden unexpected death in epilepsy   SUDEP   Education   Neurology residency   Residency training  

摘要： We evaluated baseline sudden unexpected death in epilepsy (SUDEP) knowledge and counseling practices among national and international adult neurology trainees with a 12-question online survey. The survey was emailed to all 169 U.S. neurology residency program directors and select international neurology/epilepsy program leaders. Program leaders were asked to distribute the survey link to adult neurology trainees. There were 161 respondents in the U.S. and 171 respondents outside the U.S. The latter were from 25 Latin American, European, Asian, and African countries. More than 90% of all trainees reported familiarity with SUDEP definition. Familiarity with SUDEP risk factors and mitigation measures ranged from 56% to 67% across these groups, with international trainees slightly more familiar with risk factors (67% vs. 61% in U.S.) but less familiar with mitigation measures (56% vs. 63% in U.S.). Approximately half of national (49%) and international (54%) trainees rarely or never counseled patients on SUDEP. Less than half of national (44%) and international (41%) trainees were educated about SUDEP. Many U.S. and adult neurology trainees remain unfamiliar with SUDEP risk factors and mitigation measures. Sudden unexpected death in epilepsy counseling falls below recommended standards. We suggest that worldwide neurology training programs' leaderships consider improving SUDEP education targeted at adult neurology trainees. (c) 2021 Elsevier Inc. All rights reserved.

关键词： Valve disease   Endocarditis   Neurological complication   Stroke  

摘要： Methods. - In a prospective, single-centre study in a referral centre for IE, all patients with IE underwent systematic screening for neurological complications. The primary outcome was 6-month death. In patients presenting with neurological complications, the prognosis according to surgical status was analysed and a Cox regression model used to identify variables predictive of death. Results. - Between April 2014 and January 2018, 351 patients with a definite diagnosis of left sided IE were included. Ninety-four patients (26.8%) presented with at least one neurological complication. Fifty-nine patients (17.7%) died during 6-month follow-up. Six-month mortality rates did not differ significantly between patients with and without neurological complications (P = 0.60). Forty patients had a temporary surgical contraindication because of neurological complications. During the period of surgical contraindication, seven of these patients (17.5%) died, six (15.0%) presented a new embolic event, and 12 (30.0%) presented cardiac or septic deterioration. In multivariable analysis, predictive factors of death in patients presenting with neurological complications were temporary surgical contraindication (hazard ratio 7.36, 95% confidence interval 1.61-33.67;P = 0.010) and presence of a mechanical prosthetic valve (hazard ratio 16.40, 95% confidence interval 2.22-121.17;P = 0.006). Conclusions. - Patients with a temporary surgical contraindication due to neurological complications had a higher risk of death and frequent major complications while waiting for surgery. When indicated, the decision to postpone surgery in the early phase should be weighed against the risk of infectious or cardiac deterioration. (c) 2021 Elsevier Masson SAS. All rights reserved.

关键词： Apoptotic markers   Histological investigations   Oxidative stress   Physalis   Rats   Streptozotocin‐   induced diabetes  

摘要： Neuropathy is considered a critical complication of diabetes mellitus (DM). Scientific studies are needed to relieve these painful complications. The current study aims to estimate the ameliorative role of Physalis juice (PJ) against neurological impairment in streptozotocin (STZ)-induced diabetic rats. Type 1 DM was induced after one week of injecting rats with 55 mg STZ/kg body weight. PJ-treated rats were orally administered 5 ml PJ/kg body weight per day for 28 days after induction of diabetes. A small piece of the cerebral cortex of rats was fixed and used for histopathological investigations. The remaining portion of the cerebral cortex was homogenized for biochemical and molecular analyses. As compared to the controls, STZ-injected rats showed significant elevations in the levels of blood glucose, tumor necrosis factor alfa, interleukin-1 beta, malondialdehyde, nitric oxide, and expression levels of caspase-3 and B-cell lymphoma-2 associated X-protein. Additionally, remarkable declines in the levels of brain-derived neurotrophic factor, monoamines, B-cell lymphoma-2, glutathione, as well as the activities and gene expression levels of superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase in STZ-treated rats were reported. Moreover, some histopathological alterations were observed in the brain cortex of the STZ-treated rats. On the other hand, the administration of PJ substantially reduced the blood glucose and alleviated the above-mentioned alterations in all the studied parameters of the cerebral cortex. In conclusion, an oral administration of 5 ml PJ/kg revealed a neuroprotective action against neurodegenerative diabetes-induced complications in rats, which might be due to the reported antioxidative and anti-inflammatory actions of PJ. Thus, further therapeutic studies are recommended to apply PJ in the treatment regimen of diabetes.

关键词： Stem cells   Extracellular vesicles   Secretome   Delivery   Central    nervous system   Peripheral    nervous system   Repair   Biomaterials   Clinical trials  

摘要： One of the most explored strategies to cure neurological dis-orders is the transplantation of stem cells and their derived products. Different stem cells, as well as their extracellular vesicles (EV), modified or not, have been administrated in a large array of preclinical neurological disorder models. EV represent the hope of a "cell-free" therapy that would combine the therapeutic potential of stem cells without their drawbacks. Stem cells and EV showed various degrees of efficiency but, overall, provided benefits and improvements. The administra-tion route has a considerable impact on stem cell and EV safety and therapeutic effect. However, despite evidences of preclinical success, the different strategies developed based on stem cells to treat neurological disorders do not exactly recapitulate in clinical trials. Discrepancies between preclinical and clinical experimental conditions and settings, cell avail-ability and difficulties to scale up and to produce cells and EV in a Good Manufacturing Practices (GMP) environment limit translation.