关键词： 2019新型冠状病毒感染   奥密克戎   救治体系   重症   护理  

摘要： 尽管新型冠状病毒奥密克戎变异株致病力下降，但其传播性强，由于我国人口基数大，其所引起的重症、危重症病例急剧增多对医疗系统提出巨大挑战，如何构建高效的救治体系，提高患者的生存率，是迫切解决的难题。为此，中山大学附属第三医院组织院内相关专家撰写本诊疗方案，规范患者收治流程，甄别重症、危重症病例，制定救治方案及护理、康复指引。

关键词： infectious disease   coronavirus   2019-nCoV   SARS-CoV-2   observational   risk of bias  

摘要： There have been reports of poor-quality research during the COVID-19 pandemic. This registered report assessed design characteristics of registered clinical trials for COVID-19 compared to non-COVID-19 trials to empirically explore the design of clinical research during a pandemic and how it compares to research conducted in non-pandemic times. We did a retrospective cohort study with a 1 : 1 ratio of interventional COVID-19 registrations to non-COVID-19 registrations, with four trial design outcomes: use of control arm, randomization, blinding and prospective registration. Logistic regression was used to estimate the odds ratio of investigating COVID-19 versus not COVID-19 and estimate direct and total effects of investigating COVID-19 for each outcome. The primary analysis showed a positive direct and total effect of COVID-19 on the use of control arms and randomization. It showed a negative direct effect of COVID-19 on blinding but no evidence of a total effect. There was no evidence of an effect on prospective registration. Taken together with secondary and sensitivity analyses, our findings are inconclusive but point towards a higher prevalence of key design characteristics in COVID-19 trials versus controls. The findings do not support much existing COVID-19 research quality literature, which generally suggests that COVID-19 led to a reduction in quality. Limitations included some data quality issues, minor deviations from the pre-registered plan and the fact that trial registrations were analysed which may not accurately reflect study design and conduct. Following in-principle acceptance, the approved stage 1 version of this manuscript was pre-registered on the Open Science Framework at https://***/10.17605/***/5YAEB. This pre-registration was performed prior to data analysis.

关键词： 乙类传染病   冠状病毒感染   新型冠状病毒   劳动用工   卫生健康   肺炎   传染病的预防   控制措施  

摘要： 2022年12月26日,国家卫生健康委发布公告:自2023年1月8日起,新型冠状病毒感染从“乙类甲管”调整为“乙类乙管”。2020年1月20日,经报国务院批准后国家卫生健康委发布公告,将新型冠状病毒肺炎(简称“新冠肺炎”)纳人《中华人民共和国传染病防治法》规定的乙类传染病,并采取甲类传染病的预防、控制措施。

关键词： 新型冠状病毒肺炎   金线莲液   喷雾   外治法  

摘要： 目的观察金线莲液(喷雾用)治疗新型冠状病毒肺炎(COVID-19)的疗效。方法选取COVID-19患者78例,采用随机数字表法分为观察组和对照组各39例。对照组予以相应的中药配方颗粒剂口服治疗,观察组在对照组的基础上加用金线莲液喷咽喉部,2组疗程均为6 d。结果与对照组比较,观察组咽痛消失时间、咳嗽缓解时间、核酸转阴时间均明显缩短(P<0.05),第10天、第14天核酸转阴率明显提高(P<0.01)。结论金线莲液(喷雾用)可改善COVID-19患者症状,促进病毒核酸转阴。

关键词： 原发性肾病综合征   呼吸道合胞病毒   新型冠状病毒   肺炎链球菌   肺炎支原体  

摘要： 原发性肾病综合征(PNS)是儿童肾小球疾病最常见的类型之一,也是导致中国儿童慢性肾衰竭的重要原因。由于自身免疫失调和使用糖皮质激素、免疫抑制剂等原因,PNS患儿较普通患儿更易发生呼吸道感染。不同的病原体对PNS患儿疾病的影响作用及机制各不相同。该文主要从病毒、细菌、支原体等病原体对PNS患儿的影响进行综述,为改善PNS患儿的预后提供理论依据。