关键词： 新型冠状病毒肺炎   无创呼吸机   炎症反应   肺功能   血气指标   临床症状  

摘要： 目的:探究无创呼吸机联合常规药物治疗对新型冠状病毒肺炎(2019-nCoV)患者炎症反应、肺功能的影响.方法:选取2022年10月-2023年3月本院收治的2019-nCoV患者84例,按随机数字表法分为对照组(42例)予以常规药物治疗(甲泼尼龙注射液),在此基础上,观察组(42例)加用无创呼吸机治疗,两组持续治疗14 d.对比两组临床疗效、炎症反应、肺功能、临床症状消失时间、血气指标.结果:观察组临床总有效率(92.86％)高于对照组(76.19％),差异有统计学意义(P<0.05);治疗后,观察组白介

关键词： 重型新型冠状病毒感染   危重型新型冠状病毒感染   抗病毒药物   免疫治疗  

摘要： 新型冠状病毒感染(Corona Virus Disease 2019,COVID-19)是国际关注的突发公共卫生紧急情况,危害着人们的生命健康.为了探索重型及危重型COVID-19有效的药物治疗,全球已开展了多项涉及重型及危重型COVID-19药物治疗的临床研究,包括阿兹夫定、氢溴酸氘瑞米德韦片、瑞德西韦、莫诺拉韦、奈玛特韦/利托那韦、先诺特韦片/利托那韦片、巴瑞替尼、托珠单抗等药物.此外康复者恢复期血浆、免疫球蛋白、糖皮质激素等均用于重型及危重型COVID-19的治疗.本文综述了近来有关重型及危重型CO

关键词： 重症患者   创伤骨科   发热患者   新型冠状病毒   审稿专家   奉献精神   通讯编委   疫情  

摘要： 乌飞兔走,白驹过隙。值此新年肇启、万象更新的时刻,我谨代表《中华创伤骨科杂志》编辑委员会,向多年来一直关心本刊建设与发展的杂志顾问、编委、通讯编委、审稿专家及广大读者表示由衷的谢意!致以节日的问候和新年的祝福!同时向仍奋战在抗疫一线的创伤骨科同道们致敬!自2019年底新型冠状病毒爆发,2020、2021、2022年,抗疫是连续三年的年度主题,疫情持续而广泛地影响着我们的生活与工作。正值年末岁初,我们刚刚经历过的无数发热患者、无数重症患者瞬间犹如潮水一般冲向医院,涌向了负荷满载的医务人员。面对疫情的冲击,大量医务人员只能强撑身体、带病坚持工作;面对人手不足和严重减员,无数医务人员带阳工作、坚守岗位:发着烧给患者看病、打着点滴给患者开医嘱、吸着氧给患者配药;为了大量重症患者得到及时的救治,几乎所有的医院不分科室、不分专业、全院打通,经过简单培训全部收治新冠危重症患者。中国1400万医务人员,再一次展现出了无与伦比的职业牺牲与奉献精神。

关键词： 肺炎   新型冠状病毒   疫情防控   妇产专科医院   线上线下一体化  

摘要： 本文回顾性分析了2022年3-5月间上海交通大学医学院附属国际和平妇幼保健院(简称国妇幼)的线上、线下医疗服务就诊量,总结疫情防控相关经验,结合妇产专科医院特点,建立并完善一套快速处置、精准管控、有效救治、平战结合的孕产妇保障及应急处置工作机制。通过创建线上、线下融合模式下的疫情防控措施,国妇幼实现了医疗工作不停摆,就医流程顺畅有序,硬件设施改造升级,医务人员疫情防控处置能力有效提升,取得了良好的社会效益。线上、线下融合的疫情防控模式符合妇产专科医院实际情况,有效保障了上海市部分地区孕产妇的安全。

关键词： ChAdOx1 nCoV vaccine   Adverse event   Headache   Cutaneous hemorrhage  

摘要： Objectives: Fatal complications have occurred after vaccination with ChAdOx1 nCoV-19, a vaccine against Covid-19. Vaccine-induced immune thrombotic throm-bocytopenia (VITT) with severe outcome is characterized by venous thrombosis, predominantly in cerebral veins, thrombocytopenia and anti-PF4/polyanion anti-bodies. Prolonged headaches and cutaneous hemorrhages, frequently observed after the ChAdOx1 nCoV-19 vaccine, have therefore caused anxiety among vaccin-ees. We investigated whether these symptoms represent a mild form of VITT, with a potential for aggravation, e.g. in case of a second vaccination dose, or a different entity of vaccine complications Materials and methods: We included previously healthy individuals who had a combination of headache and spontaneous severe cutaneous hemorrhages emerging after the 1st dose of the ChAdOx1 nCoV-19 vac-cine. Twelve individuals were found to meet the inclusion criteria, and a phone interview, cerebral MRI, assessment of platelet counts, anti PF4/polyanion antibod-ies and other laboratory tests were performed. Results: None of the symptomatic vaccinees had cerebral vein thrombosis, hemorrhage or other pathology on MRI. Platelet counts were within normal range and no anti-PF4/polyanion platelet acti-vating antibodies were found. Moreover, vasculitis markers, platelet activation markers and thrombin generation were normal. Furthermore, almost all symptoms resolved, and none had recurrence of symptoms after further vaccination with mRNA vaccines against Covid-19. Conclusions: The combination of headaches and subcutaneous hemorrhage did not represent VITT and no other specific coagulation disorder or intracranial pathology was found. However, symptoms initially mim-icking VITT demand vigilance and low threshold for a clinical evaluation combined with platelet counts and D-dimer.(c) 2022 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY license (http://***/licenses/by/4.0

关键词： 新型冠状病毒   病毒病   防治   手册  

ISBN: (纸本)9787517139409

摘要： 为指导人们有效应对新冠疫情的新变化、新冲击，北京大学第三医院组织呼吸内科、感染疾病科等诸多科室权威专家整理撰写了《新冠病毒感染者自我照护手册》一书。本书内容涵盖了新冠感染后的临床表现、诊断、治疗、康复及就医注意事项等，以期对新冠感染者尤其是孕产妇、婴幼儿等特殊人群和患有肿瘤以及基础疾病患者的自我照护、居家康复进行指导，并有所帮助。

关键词： SARS-CoV-2   2019-nCoV   rapid test   diagnostic accuracy   meta-analysis   metasynthesis   COVID-19   low-and middle-income countries  

摘要： Background: Amid all public health measures to contain COVID-19, the most challenging has been how to break the transmission chain. This has been even more challenging in low-and middle-income countries (LMICs). A public health emergency warrants a public health perspective, which comes down to prevention. Rapid mass testing has been advocated throughout the pandemic as a way to promptly deal with asymptomatic infections, but its usefulness in LMICs is yet to be fully ***: The study objectives of this paper are to (1) investigate the impact of the different rapid mass testing options for SARS-CoV-2 that have been delivered at point of care in LMICs and (2) evaluate the diagnostic safety (accuracy) of rapid mass testing for SARS-CoV-2 in LMICs. Methods: This review will systematically search records in PubMed, EBSCOhost, Cochrane library, Global Index Medicus COVID-19 Register, and Scopus. Records will be managed using Mendeley reference manager and SWIFT-Review. Risk of bias for randomized controlled trials will be assessed using the RoB 2 assessment tool, while nonrandomized interventions will be assessed using the tool developed by the Evidence Project. A narrative approach will be used to synthesize data under the first objective, and either a meta-analysis or synthesis without meta-analysis for the second objective. Tables, figures, and textual descriptions will be used to present findings. The overall body of evidence for the first objective will be assessed using the Grading of Recommendations Assessment, Development, and Evaluation-Confidence in the Evidence from Reviews of Qualitative research (GRADE-CERQual) approach, and for the second objective using ***: The screening of records has been finalized. We hope to finalize the synthesis by the end of February 2023 and to prepare the manuscript for publication by April 2023. The study will be reported in accordance with standard guidelines for the reporting of systematic reviews. Rev