关键词： 新型冠状病毒肺炎   护生   知识   护理意愿   课程思政  

摘要： 目的:了解在校大专护生新型冠状病毒肺炎相关知识与护理意愿,分析其影响因素,以期为护生的职业素养和思想政治教育提供参考依据。方法:采用便利抽样的方法,通过问卷星网上发布问卷,对湖南省2所医学院校的专科护生963人进行调查。结果:大专护生对新冠肺炎相关知识平均得分为(23.58±1.24)分,新冠肺炎各知识条目的平均知晓率为85.91%。963名调查对象中,28.1%的护生不愿护理新冠肺炎患者,单因素分析结果显示,影响大专护生护理新冠肺炎患者意愿的影响因素为不同年级、政治面貌、对新冠肺炎的紧张恐惧程度(P<0.05)。通过多因素Logistic回归分析显示,不同年级、政治面貌、对新冠肺炎的紧张恐惧、新冠肺炎知识总分是大专护生护理意愿的影响因素。结论:大专护生对新冠肺炎的知识还需有针对性地强化,对传染病患者的主动服务意识还有待加强,建议将“课程思政”融入专业课程教学中,从而提高护生的思想水平、政治觉悟、道德品质、文化素养,进而提升所有护生主动服务的意识。

关键词： 疫情下   家政行业   发展形势   分析  

摘要： 2020年一场突如其来的疫情打乱了所有人的脚步,给全世界人民的生活带来了严重的影响。到目前为止,在中央的领导下和全国人民的共同努力下,疫情得到很好的控制。尽管如此,中国经济的增长仍然受到相当大的影响。受新冠疫情影响,由于人与人的直接接触受限,家政服务业受到较大地冲击,行业发展面临着巨大挑战,疫情的暴发也为家政服务行业提质扩容转型升级提供了新的转机,从全流程数字化改造、服务标准规范程度提升、服务人员精细化管理等方面催生了家政服务行业数字化智能化高质量发展的机遇。

关键词： 新型冠状病毒   痰液   细胞学   液基  

摘要： 随着人类社会快速发展,致病微生物也在不断演变,严重危害人类健康。新型冠状病毒肺炎[1](COVID-19)为新发急性呼吸道传染病,可以通过呼吸道飞沫传播、密切接触、密闭环境中高浓度气溶胶等传播,已成为全球性重大的公共卫生事件。面临如此严峻的疫情,给病理科痰液样本的制作带来了风险。因此如何对送检的痰样进行消毒和灭活,成为我们更为关注的问题。

关键词： humoral   immunogenicity   mRNA vaccine   autoimmune rheumatic diseases  

摘要： Immunogenicity data on the mRNA SARS-CoV-2 vaccine booster after completing a primary series vaccination, other than the mRNA vaccine, in patients with autoimmune rheumatic diseases (ARDs) is scarce. In this study, we reported the humoral immunogenicity of an mRNA booster 90-180 days after completing heterologous CoronaVac/ChAdOx1 nCoV-19 (n = 19) or homologous ChAdOx1 nCoV-19 (n = 14) vaccination by measuring the anti-SARS-CoV-2 receptor binding domain (RBD) IgG levels at one and three months after mRNA booster vaccination. This study included 33 patients with ARDs [78.8% women;mean (SD) age: 42.9 (10.6) years]. Most patients received prednisolone (75.8%, mean [IQR] daily dose: 7.5 [5, 7.5] mg) and azathioprine (45.5%). The seropositivity rates were 100% and 92.9% in CoronaVac/ChAdOx1 and ChAdOx1/ChAdOx1, respectively. The median (IQR) anti-RBD IgG level was lower in the ChAdOx1/ChAdOx1 group than in the CoronaVac/ChAdOx1 group (1867.8 [591.6, 2548.6] vs. 3735.8 [2347.9, 5014.0] BAU/mL, p = 0.061). A similar trend was significant in the third month [597.8 (735.5) vs. 1609.9 (828.4) BAU/mL, p = 0.003]. Minor disease flare-ups occurred in 18.2% of the patients. Our findings demonstrated satisfactory humoral immunogenicity of mRNA vaccine boosters after a primary series, with vaccine strategies other than the mRNA platform. Notably, the vaccine-induced immunity was lower in the ChAdOx1/ChAdOx1 primary series.

关键词： Adams-Bashforth-Moulton method   COVID-19 disease   existence theorems   numerical simulations   stability analysis   uniqueness theorems  

摘要： Coronavirus infection (COVID-19) is a considerably dangerous disease with a high demise rate around the world. There is no known vaccination or medicine until our time because the unknown aspects of the virus are more significant than our theoretical and experimental knowledge. One of the most effective strategies for comprehending and controlling the spread of this epidemic is to model it using a powerful mathematical model. However, mathematical modeling with a fractional operator can provide explanations for the disease's possibility and severity. Accordingly, basic information will be provided to identify the kind of measure and intrusion that will be required to control the disease's progress. In this study, we propose using a fractional-order SEIARPQ model with the Caputo sense to model the coronavirus (COVID-19) pandemic, which has never been done before in the literature. The stability analysis, existence, uniqueness theorems, and numerical solutions of such a model are displayed. All results were numerically simulated using MATLAB programming. The current study supports the applicability and influence of fractional operators on real-world problems.

摘要： Background COVID-19 vaccine rollout is lagging in Africa, where there has been a high rate of SARS-CoV-2 infection. We aimed to evaluate the effect of SARS-CoV-2 infection before vaccination with the ChAdOx-nCoV19 (AZD1222) vaccine on antibody responses through to 180 days. Methods We did an unmasked post-hoc immunogenicity analysis after the first and second doses of AZD1222 in a randomised, placebo-controlled, phase 1b-2a study done in seven locations in South Africa. AZD1222 recipients who were HIV-uninfected, were stratified into baseline seropositive or seronegative groups using the serum anti-nucleocapsid (anti-N) immunoglobulin G (IgG) electroluminescence immunoassay to establish SARS-CoV-2 infection before the first dose of AZD1222. Binding IgG to spike (anti-S) and receptor binding domain (anti-RBD) were measured before the first dose (day 0), second dose (day 28), day 42, and day 180. Neutralising antibody (NAb) against SARS-CoV-2 variants D614G, beta, delta, gamma, and ***.V2, and omicron BA1 and BA.4 variants, were measured by pseudovirus assay (day 28, day 42, and day 180). This trial is registered with ***, NCT04444674, and the Pan African Clinicals Trials Registry, PACTR202006922165132. Findings Of 185 individuals who were randomly assigned to AZD1222, we included 91 individuals who were baseline seropositive and 58 who were baseline seronegative, in the final analysis. In the seropositive group, there was little change of anti-S IgG (and anti-RBD IgG) or neutralising antibody (NAb) titres at day 42 compared with at day 28. Anti-S (and anti-RBD) IgG geometric mean concentrations (GMCs) were higher throughout in the seropositive compared with the seronegative group, including at day 180 (GMCs 517middot8 [95% CI 411middot3-651middot9] vs 82middot1 [55middot2-122middot3] BAU/mL). Also D614G NAb geometric mean titres (GMTs) were higher in the seropositive group than the seronegative group, as was the percentage with titres of at least 185

关键词： Antibodies against platelet factor 4 (PF4)   Thrombocytopenia syndrome (TTS)   Vaccination   Death   AstraZeneca   COVID-19   Forensic medicine  

摘要： We report a case of cerebral venous sinus thrombosis, bilateral adrenal hemorrhage, and thrombocytopenia in a 70-year-old man found dead. He had previously received the ChAdOx1 nCoV-19 vaccine (Vaxzevria (R), AstraZeneca) 18 days before, and had since developed unspecific and undiagnosed characteristics of what proved to be a rare case of vaccine-associated thrombocytopenia with thrombosis syndrome (TTS). He was found dead 1 week after the beginning of symptoms (day 25 post-vaccine). Autopsy yielded venous hemorrhagic infarction with the presence of thrombi within dural venous sinuses, and extensive hemorrhagic necrosis of the central part of the adrenal glands. Antibodies against platelet factor 4 (PF4) were strongly positive in postmortem fluids, as measured with an enzyme-linked immunosorbent assay (ELISA). This difficult diagnosis is usually made during the patient's lifetime. After eliminating differential diagnoses, we concluded on a fatal case of vaccine-induced immune TTS with positive anti-PF4 antibodies in cadaveric blood, 3 weeks after ChAdOx1 nCoV-19 vaccination. Specific search for anti-PF4 antibodies in cadaveric blood appears therefore paramount to assess postmortem cases of TTS associated with anti-COVID vaccines.

关键词： COVID-19 vaccine   vaccine-induced thrombocytopenia and thrombosis   VITT   Asian  

摘要： Anti-platelet factor 4 (anti-PF4) antibodies were identified as pathogenic antibodies for vaccine-induced immune thrombocytopenia and thrombosis (VITT) in subjects receiving ChAdOx1 nCoV-19 vaccinations. We performed a prospective cohort study to determine the prevalence of anti-PF4 and the effect of the ChAdOx1 nCoV-19 vaccine on anti-PF4 in healthy Thai subjects. Anti-PF4 antibodies were measured before and four weeks after receiving the first vaccination. Participants with detectable antibodies were scheduled for repeat anti-PF4 analysis at 12 weeks after the second vaccination. Of 396 participants, ten participants (2.53%;95% confidence interval [CI], 1.22-4.59) were positive for anti-PF4 before receiving vaccinations. Twelve people (3.03%;95% CI, 1.58-5.23) had detectable anti-PF4 after the first vaccination. There was no difference in the optical density (OD) values of anti-PF4 antibodies when comparisons were made between pre-vaccination and four weeks after the first vaccination (p = 0.0779). There was also no significant difference in OD values in participants with detectable antibodies. No subjects experienced thrombotic complications. Pain at the injection site was associated with an increased risk of being anti-PF4 positive at an odds ratio of 3.44 (95% CI, 1.06-11.18). To conclude, the prevalence of anti-PF4 was low in Thais and did not significantly change over time.

关键词： 新型冠状病毒   病毒病   心理干预  

ISBN: (纸本)9787560451183

摘要： 本书共12章，内容包括：应激障碍、焦虑情绪管理、失眠与睡眠管理、强迫障碍应对策略、疑病障碍应对策略、躯体形式障碍应对策略、抑郁障碍应对策略、药物滥用的处置、心理健康促进、压力管理等。

关键词： Vogt-Koyanagi-Harada disease   COVID-19 vaccine   ChAdOx1 nCoV-19   mRNA-1273   Ocular adverse events  

摘要： Almost all vaccines have been reported to be associated with ocular inflamma-tion, which has caused some concern regarding global mass COVID-19 vaccination efforts. Vogt-Koyanagi-Harada disease (VKHD) is a granulomatous inflammation caused by an autoim-mune response against antigens in melanocytes, including those in the eyes. The mechanism by which COVID-19 vaccines are associated with VKHD is still unclear. Here, we report two cases of VKHD following COVID-19 vaccination. The first is a case of probable VKHD that presented with bilateral vision loss after administration of the adenovirus-vectored vaccine ChAdOx1 nCoV-19 (AstraZeneca). The condition improved after intravenous methylprednisolone 1 g daily for 3 days, followed by oral methotrexate and a slow taper of oral corticosteroids. The second case is a patient with an established diagnosis of well-controlled VKHD who developed a reactiva-tion of the disease after receiving the mRNA-based vaccine (mRNA-1273, Moderna). VKHD is a potential ocular event that could follow COVID-19 vaccination. Awareness of this association is key to early detection and treatment to prevent loss of vision. (c) 2023 Elsevier Masson SAS. All rights reserved.