关键词： IoT   Internet of Things   Healthcare technology   Communication sensor technology adoption  

摘要： A serious effect on people's life, social communication, and surely on medical staff who were forced to monitor their patients' status remotely relying on the available technologies to avoid potential infections and as a result reducing the workload in hospitals. this research tried to investigate the readiness level of healthcare professionals in both public and private Iraqi hospitals to utilize IoT technology in detecting, tracking, and treating 2019-nCoV pandemic, as well as reducing the direct contact between medical staff and patients with other diseases that can be monitored remotely.A cross-sectional descriptive research via online distributed questionnaire, the sample consisted of 113 physicians and 99 pharmacists from three public and two private hospitals who randomly selected by simple random sampling. The 212 responses were deeply analyzed descriptively using frequencies, percentages, means, and standard *** results confirmed that the IoT technology can facilitate patient follow-up by enabling rapid communication between medical staff and patient relatives. Additionally, remote monitoring techniques can measure and treat 2019-nCoV, reducing direct contact by decreasing the workload in healthcare industries. This paper adds to the current healthcare technology literature in Iraq and middle east region an evidence of the readiness to implement IoT technology as an essential technique. Practically, it is strongly advised that healthcare policymakers should implement IoT technology nationwide especially when it comes to safe their employees' *** medical staff are fully ready to adopt IoT technology as they became more digital minded after the 2019-nCoV crises and surely their knowledge and technical skills will be improved spontaneously based on diffusion of innovation perspective.

关键词： 新型冠状病毒   轻型   普通型   皖北地区   宣肺清化法   三因制宜  

摘要： 目的：观察宣肺清热化湿法对40例皖北地区新型冠状病毒感染轻型及普通型患者的临床疗效。方法：纳入安徽省宿州市第三人民医院救治的新型冠状病毒感染轻型及普通型患者40例，所有患者均在《新型冠状病毒肺炎诊疗方案（试行第九版）》（以下称《诊疗方案》）基础上，以传统中医“三因治宜”理论为指导，根据皖北地区特点，以宣肺清热化湿为法，施以“新清肺排毒汤”为基本方进行特殊调配。比较和分析治疗前后各项临床指标，采用SPSS 26.0统计软件对各指标数据进行统计分析。结果：所有患者经过治疗，病毒核酸检测均转阴后出院，轻型平均住院时间（9.81±2.90）d，连续两次核酸转阴时间（11.11±4.11）d，总有效率85.19%。普通型平均住院时间（10.54±2.54）d，连续两次核酸转阴时间（10.23±2.74）d，总有效率84.62%。治疗后白细胞计数升高、淋巴细胞百分比升高、C反应蛋白计数降低，前后比较差异有统计学意义。治疗过程中密切关注肝肾功能，未发现造成肝肾损伤者。结论：针对不同地域，不同气候，不同体质人群感染新冠病毒反应的不同特性，在《诊疗方案》的基础上制定和更新防治新策略和新方法，充分发挥中医辨证施治、个性灵活的优势，可以更好的应对新冠病毒不断变异产生的新变化和新特征。

关键词： Caputo derivative   equilibrium points   fractional mathematical model   stability analysis  

摘要： Since December 2019, the whole world has been facing the big challenge of Covid-19 or 2019-nCoV. Some nations have controlled or are controlling the spread of this virus strongly, but some countries are in big trouble because of their poor control strategies. Nowadays, mathematical models are very effective tools to simulate outbreaks of this virus. In this research, we analyze a fractional-order model of Covid-19 in terms of the Caputo fractional derivative. First, we generalize an integer-order model to a fractional sense, and then, we check the stability of equilibrium points. To check the dynamics of Covid-19, we plot several graphs on the time scale of daily and monthly cases. The main goal of this content is to show the effectiveness of fractional-order models as compared to integer-order dynamics.

摘要： In the phase 3 trial of the AZD1222 (ChAdOx1 nCoV-19) vaccine conducted in the U.S., Chile, and Peru, anti-spike binding IgG concentration (spike IgG) and pseudovirus 50% neutralizing antibody titer (nAb ID50) measured four weeks after two doses were assessed as correlates of risk and protection against PCR-confirmed symptomatic SARS-CoV-2 infection (COVID-19). These analyses of SARS-CoV-2 negative participants were based on case-cohort sampling of vaccine recipients (33 COVID-19 cases by 4 months post dose two, 463 non-cases). The adjusted hazard ratio of COVID-19 was 0.32 (95% CI: 0.14, 0.76) per 10-fold increase in spike IgG concentration and 0.28 (0.10, 0.77) per 10-fold increase in nAb ID50 titer. At nAb ID50 below the limit of detection (< 2.612 IU50/ml), 10, 100, and 270 IU50/ml, vaccine efficacy was -5.8% (-651%, 75.6%), 64.9% (56.4%, 86.9%), 90.0% (55.8%, 97.6%) and 94.2% (69.4%, 99.1%). These findings provide further evidence towards defining an immune marker correlate of protection to help guide regulatory/approval decisions for COVID-19 vaccines.

关键词： 新型冠状病毒感染   群体免疫   新冠疫苗   治未病   中医药   防治  

摘要： 自2019年12月新型冠状病毒感染暴发以来,疫情迅速蔓延至世界各地,呈全球大流行态势,严重威胁人类生命健康,成为全球性的重大公共卫生事件.在早期无特效药物和疫苗的情况下,除了给予对症、支持治疗外,群体免疫和中医药治未病成为可供选择的防疫策略.通过厘清群体免疫的概念及分类,回顾3年来人工群体免疫及中医药治未病在疫情防控中的应用情况,指出当前疫苗时代实现人工群体免疫所面临的挑战及对策,总结中医药治未病抗疫经验成果,分析比较二者的异同点,最终认为中医药治未病全方位指导疫病的预防、治疗及康复工作,可以有效弥补人工群体免疫的不足.从人工群体免疫与中医药治未病两方面共同发力,能够助力突发传染病应急防控体系建设,为后续抗疫工作及应对未来可能出现的新疫情提供有益借鉴和储备.

关键词： 新型冠状病毒肺炎   高龄   急性心力衰竭   心肌损伤  

摘要： 2022年春季新型冠状病毒Omicron变异株在上海爆发了大流行。合并各类基础疾病的老年患者疫苗接种率较低,是本次流行的主要易感人群,且易进展为危重症。因此救治老年危重患者成为目前临床诊疗新型冠状病毒肺炎的难点之一。本报道是1例超高龄新型冠状病毒肺炎患者,病程由轻症进展为重症,并发急性心力衰竭、心源性休克。笔者结合文献回顾性分析其病因和临床特征,分享基层医院诊疗高龄新型冠状病毒肺炎危重症的经验与得失,为救治新型冠状病毒肺炎危重症合并心血管并发症提供参考依据。

关键词： 气膜舱实验室   新型冠状病毒感染   感染管理   职业暴露  

摘要： 气膜舱实验室作为新型冠状病毒及其变异株核酸检测的重要工具,是新型冠状病毒感染疫情防控中的关键性医疗资源。气膜舱实验室内的医务人员、保安、保洁、维修工人和志愿者等工作人员与标本接触频率高,因此感染新型冠状病毒的风险较高。为降低这种风险,该文以南充气膜舱实验室运行流程为线索,对个人防护用品的穿脱、环境卫生的管理、使用后物品的管理、医疗废物的管理、工作人员的培训管理及职业暴露后的处置流程等方面的感染管理措施进行了探讨,并分析运行中的常见问题,以为其他气膜舱实验室的构建和管理提供参考。

关键词： 抗体,病毒   新型冠状病毒肺炎   中和抗体   鸡尾酒疗法   AZD7442   蛋白结构  

摘要： 新型冠状病毒感染(COVID-19)由新型冠状病毒(SARS-CoV-2)感染引起,给全球带来巨大的防控压力。AZD7442采用抗体鸡尾酒疗法,由替沙格韦单抗(Tixagevimab)和西加韦单抗(Cilgavimab)两个长效中和抗体协同发挥中和作用,兼具预防和治疗价值。本综述总结AZD7442有效中和SARS-CoV-2的结构特征及其药效学研究,以期深入理解AZD7442对SARS-CoV-2的中和作用。AZD7442在暴露后预防及治疗方面也展现出积极的作用,是目前唯一获批用于COVID-19暴露前预防的中和抗体。鉴于AZD7442在COVID-19预防和治疗中的双重应用前景,AZD7442有望为当前SARS-COV-2感染的防治提供新的选择,同时为其他病毒感染的预防和治疗提供借鉴意义。