关键词： HEART beat   INFLAMMATORY bowel diseases   DISEASE remission  

摘要： A letter to the editor is presented in response to the article 'Heart rate recovery is impaired in patients with inflammatory bowel diseases,' by B. Sarli and colleagues in the 2016 issue.

关键词： 丙氨酰谷氨酰胺   胃肠疾病   合理性  

摘要： 目的探讨丙氨酰谷氨酰胺在胃肠疾病中使用的合理性,为临床合理用药提供借鉴经验。方法选用我院2015年12月至2016年5月运用丙氨酰谷氨酰胺治疗胃肠疾病的病例275例,对所选病例中该药品的使用适应症、使用方法、使用剂量、疗程、禁忌症等指标进行记录,并分析总结。结果 275例患者中有62例存在不合理用药情况,占所选病例22.55%,主要不合理情况为无适应症用药31例(50%),用法用量不合理共24例(38.71%)。结论医院对丙氨酰谷氨酰胺使用应加强管理,应根据病情需要并按照药品使用标准用药,促进药品的合理使用。

关键词： INFLAMMATORY bowel disease treatment   PROTON pump inhibitors   ANTIHISTAMINES  

摘要： An introduction is presented in which the author discusses the theme of the issue on the impact of acid-suppressing medications such as proton pump inhibitors and antihistamines to inflammatory bowel diseases.

关键词： 舒尿通煎剂   肛肠   尿潴留   预防   效果  

摘要： 目的分析舒尿通煎剂对肛肠疾病术后尿潴留的预防效果。方法选取2016年2月2017年2月我院收治的肛肠疾病者80例为对象,分为对照组（40例）和治疗组（40例）,对照组施予哈乐,对治疗组实施舒尿通煎剂,分析2组药物对预防肛肠疾病术后尿潴留的发生效果,比较术后疼痛视觉中的模拟评分（VAS）。结果治疗组在临床疗效中总有效率92.50%（37/40）高于对照组（P<0.05）。2组在术后2 h、5 h、8 h后的VAS的评分中,治疗组评分低于对照组（P<0.05）。结论舒尿通煎剂对肛肠疾病术后尿潴留的预防效果良好,能够减轻病患术后疼痛感。

关键词： 盐酸奥布卡因凝胶   肛肠疾病   手术后换药   疼痛  

摘要： 目的 探讨有效的盐酸奥布卡因凝胶在肛肠疾病手术后患者换药中的应用方法 .方法选本院100例行手术治疗肛肠疾病患者随机分成对照组和实验组.对照组采用肛肠疾病患者便后用痔疾洗液温水坐浴10min常规换药方式进行操作,实验组在对照组的基础上采取盐酸奥布卡因凝胶换药涂抹于患处,5min后常规方式进行操作.结果 实验组的疼痛总发生率明显低于对照组,护理满意度明显高于对照组,住院时间明显短于对照组,患者疼痛时间明显少于对照组.比较差异均具有统计学意义(P<0.05).结论 对盐酸奥布卡因凝胶在肛肠疾病患者手术后应用具有显著的疗效,可提高患者的护理满意度,缩短患者的住院时间和降低疼痛和并发症总发生率.

关键词： Crohn disease   Ulcerative colitis   Primary sclerosing cholangitis   Antibiotics  

摘要： Background: The pathogenesis of inflammatory bowel disease (IBD) is complex and involves the contribution of genetic and environmental factors. Many patients with very early onset IBD are difficult to treat. The current antibiotic medication that targets gram-negative and anaerobic bacteria provides only moderate efficacy in subsets of patients with IBD. Methods: We report a case series of 5 children with a mean age of 1.6 years (range 6 months to 2.7 years) during IBD onset, who were previously refractory to standard treatments and who received oral vancomycin with or without gentamicin. Results: Four out of 5 children demonstrated substantial therapeutic effect, and the effect was sustained in 3 children over a follow-up period of 1233 months. Conclusion: Our findings are consistent with model systems and suggest that randomized trials are required to establish whether a change in therapeutic paradigm, that is, targeting gram-positive bacteria with non-absorbable antibiotics, may have therapeutic benefits. (C) 2017 S. Karger AG, Basel

关键词： patient advocacy groups   Crohn's disease   ulcerative colitis   patients   caregivers  

摘要： Inflammatory bowel disease (IBD) - primarily Crohn's disease and ulcerative colitis - is a debilitating lifelong condition with significant health and economic costs. From diagnosis to management, IBD can cause huge psychosocial concerns to patients and their caregivers. This study reports an experience of a Crohn's patient, leading to the formation of the first IBD patient support group in Singapore and how this group has evolved in the last 4 years in supporting other IBD patients. IBD patient advocacy and/or support groups facilitate open conversations on patients' fears, concerns, preferences and needs, and may potentially improve disease knowledge and quality of life for individuals with the condition or their families.

关键词： 肛肠疾病   尿潴留   预防措施   护理2400字  

摘要： [目的]探讨肛肠疾病术后尿潴留的预防措施及护理方法[方法]选取我院收治的肛肠疾病手术患者56例,根据患者情况对所有患者开展尿潴留的预防措施及相关护理操作[结果]56例肛肠疾病患者在手术和护理期间中,仅有3例患者发生尿潴留现象[结论]实施肛肠期间对尿潴留进行预防及护理,可以有效预防尿潴留的发生,对于提高患者的生存和生活质量具有重要意义,值得在临床上进行大力推广.

关键词： Adjuvants-immunologic   biological factors   inflammatory bowel diseases   reproductive health  

摘要： Background: Although much knowledge has been gained regarding the medical and surgical management of inflammatory bowel disease (IBD), a paucity of information is available on the psychosexual issues related to IBD. The aim of this study was to evaluate the sexual health of patients with IBD who were taking immunomodulators and/or biologic agents vs patients with IBD who were not on that medication regimen. Methods: All study participants completed a validated sexual health questionnaire, the Female Sexual Function Index or the International Index of Erectile Function, to assess their subjective perception of the effect of IBD on the different domains of sexual function during the prior 1-month time period. Results: No statistically significant differences in any baseline demographic variables were found for either sex between the group taking immunomodulators/biologic agents and the nontreatment group. Among females and males, individual question responses, domain scores, and total scores showed no statistically significant differences between the 2 treatment groups. Conclusion: Our data suggest that the use of immunomodulators or biologic agents does not affect female or male sexual health. However, treatment of patients with IBD must be individualized based on the aggressive nature of the disease, treatment goals, and the tolerability of various medications.

关键词： IBD   India   Indian vegetarian   colon cancer   gut microbiota  

摘要： : The intestinal microbiota, through complex interactions with the gut mucosa, play a key role in the pathogenesis of colon carcinoma and inflammatory bowel disease (IBD). The disease condition and dietary habits both influence gut microbial diversity. : The aim of this study was to assess the gut microbial profile of healthy subjects and patients with colon carcinoma and IBD. Healthy subjects included 'Indian vegetarians/lactovegetarians', who eat plant produce, milk and milk products, and 'Indian non-vegetarians', who eat plant produce, milk and milk products, certain meats and fish, and the eggs of certain birds and fish. 'Indian vegetarians' are different from 'vegans', who do not eat any foods derived wholly or partly from animals, including milk products. : Stool samples were collected from healthy Indian vegetarians/lactovegetarians and non-vegetarians, and colon cancer and IBD patients. Clonal libraries of 16S ribosomal DNA (rDNA) of bacteria were created from each sample. Clones were sequenced from one representative sample of each group. Approximately 500 white colonies were picked at random from each sample and 100 colonies were sequenced after amplified rDNA restriction analysis. : The dominant phylum from the healthy vegetarian was Firmicutes (34%), followed by Bacteroidetes (15%). The balance was reversed in the healthy non-vegetarian (Bacteroidetes 84%, Firmicutes 4%; ratio 21:1). The colon cancer and IBD patients had higher percentages of Bacteroidetes (55% in both) than Firmicutes (26% and 12%, respectively) but lower Bacteroidetes:Firmicutes ratios (3.8:1 and 2.4:1, respectively) than the healthy non-vegetarian. Bacterial phyla of Verrucomicrobiota and Actinobacteria were detected in 23% and 5% of IBD and colon patients, respectively. : Ribosomal Database Project profiling of gut flora in this study population showed remarkable differences, with unique diversity attributed to different diets and disease conditions.