关键词： 胃肠充盈超声造影   胃十二指肠疾病   诊断价值  

摘要： 探讨分析胃肠充盈超声造影对胃十二指肠疾病的诊断价值。方法:该次研究从2020年5月开始,至2021年6月为止,通过电脑操作的方式下,在该时间段内随机选择在我院接受检查的胃十二指肠内该疾病患者80例作为入组成员,对参与本次研究的患者先后实施胃肠超声造影检查以及胃镜检查,并将胃镜检查下患者的病理组织诊断作为诊断的标准,对所有患者的胃肠超声充盈检查的检出结果进行对比与分析。结果:在使用胃肠超声充盈检查的方式所测得的十二指肠溃疡、十二指肠炎症以及十二指肠梗阻的概率分别为36.67%、33.33%、15.56%,而胃镜所测得对应的概率分别为33.33%、33.33%、17.78%,两种方法的检出率之间并没有差异存在(P>0.05);胃肠超声充盈检查与胃镜检查所开展的恶性肿瘤检出率之间并没有差异性(P>0.05);胃肠超声充盈检查与开展的病理组织检查所得疾病检出率并没有差异性(P>0.05)。结论:胃肠充盈超声造影检查能够更好的观察到患者病灶组织的血液流动学的具体变化情况,能够对毗邻的关系更好的呈现出来,同时减少了消化道内气体以及内容物对检查结果的影响,对于十二指肠疾病的检出结果拥有更加准确性,在临床拥有着较高的使用价值。

关键词： 肛肠疾病   中药熏洗疗法   高锰酸钾坐浴疗法   疗效  

摘要： 分析研究在肛肠疾病的临床治疗中的采用中药熏洗疗法的疗效评价。方法:研究时间选择2020年1月-2020年12月期间,以我院开展的肛肠疾病治疗工作开展研究,选择100例肛肠疾病患者作为研究对象进行研究。将所有患者随机分两组即观察组和对照组,比较两组的治疗情况。结果:结果均显示观察组明显优于对照组。结论:中药熏洗疗法是治疗肛肠疾病的一种有效方法,能明显缓解患者的痛苦,改善患者生存质量,疗效确切,具有一定的推广价值。

摘要： LINKED CONTENT This article is linked to Falloon et al papers. To view these articles, visit https://***/10.1111/apt.16853 and https://***/10.1111/apt.16907

摘要： LINKED CONTENT This article is linked to Hadi et al. papers. To view these articles, visit https://***/publon/10.1111/apt.16730 https://***/10.1111/apt.16900

关键词： antidepressant medication   antidepressants   anxiety   clinical practice research datalink   Crohn's disease   depression   incidence   inflammatory bowel disease   ulcerative colitis  

摘要： Background Despite high rates of depression and anxiety, little is known about the use of antidepressants amongst individuals diagnosed with inflammatory bowel disease (IBD). Aims To evaluate temporal trends in the use of antidepressants;rates of antidepressant initiation and adherence of antidepressant use to international guidelines amongst individuals with IBD. Methods This is a study of 14,525 incident IBD cases from 2004 to 2016 compared with 58,027 controls matched 1:4 for age and sex from the Clinical Practice Research Datalink. After excluding tricyclic antidepressants, we performed a Cox regression analysis to determine the risk associated with antidepressant use and logistic regression analysis to determine risk associated with antidepressant undertreatment. Results Antidepressant use amongst individuals with IBD increased by 51% during the 12-year study period, who were 34% more likely to initiate antidepressants in the year after IBD diagnosis compared with controls (aHR:1.34, 95% CI 1.21-1.49). In those with IBD starting antidepressants, 67% received treatment lasting less than the duration recommended in international guidelines, of which 34% were treated for 1 month or less. 18-24 year olds were twice as likely to discontinue treatment within 1 month compared with those aged 40-60 years (aHR:2.03, 95% CI 1.40-2.95). Socioeconomic deprivation was also associated with early treatment discontinuation (aHR:1.40, 95% CI 1.07-1.83). Conclusions In the year following IBD diagnosis individuals are significantly more likely to start antidepressants compared with controls, but treatment duration fell short of recommendations in the majority. Better integration of services may benefit individuals with IBD and psychiatric comorbidity.

摘要： LINKED CONTENT This article is linked to Wang et al papers. To view these articles, visit https://***/10.1111/apt.16741 and https://***/10.1111/apt.16919

摘要： Very early onset inflammatory bowel disease (VEO-IBD) is diagnosed in children < 6 years of age, and in rare cases may be due to an identifiable monogenic cause. Recent advances in genetic testing have allowed for more accurate diagnosis, with as many as 100 genes now known to be associated with monogenic inflammatory bowel disease. These genes are involved in many immune pathways and thus may represent potential avenues for targeted precision medicine with pharmacologic treatments aimed at these. This review describes the broad classifications of monogenic disorders known to cause VEO-IBD, as well as empiric and disease-specific medical therapies. These include immune-modulating or immunosuppressant medications, nutritional therapy, surgery, and hematopoietic stem cell transplantation. We aim to provide an overview of the current state of targeted therapy for VEO-IBD.

摘要： LINKED CONTENT This article is linked to Wang et al papers. To view these articles, visit https://***/10.1111/apt.16741 and https://***/10.1111/apt.16888