关键词： CARRIER STATE   CEREBROSPINAL FLUID   CHILD   EPIDEMIOLOGY   NEUTRALIZATION TESTS   POLIOMYELITIS, BULBAR   POLIOVIRUS   VIRUS CULTIVATION  

摘要： Three days after her brother developed bulbospinal poliomyelitis, a 4-year-old Negro girl was examined because of fever and abdominal pain. Neurological examination was negative. Poliovirus type 1 was isolated from cerebrospinal fluid (CSF), throat swabs, and a later stool specimen, but not from serum obtained on the same day as the CSF. Although echoviruses and coxsackieviruses have been detected frequently in human CSF, poliovirus has been detected in CSF in only 7 well-documented cases. Several possible explanations for the presence of poliovirus in CSF are discussed, of which none appear to be satisfactory. The mode of entry of virus into the CSF remains unknown.

关键词： Infectious Disease   Virus Infection   Virus Type   Emotional Stress   Poliomyelitis  

摘要： Stress induced in mice by avoidance-learning for 3[long dash]4 weeks resulted in statistically significant increase of susceptibility to poliomyelitis virus type 2 when inoculated intravenously. When the stress period was reduced to 6 hours the susceptibility was unaffected.

关键词： Infectious Disease   Secondary Antibody   Chloramphenicol   Antibody Response   Spleen Cell  

摘要： Membrane cultures of separated spleen cells, from rabbits injected once with poliovirus, formed antibody in vitro for 2-3 weeks. Restimulation of spleen cells in suspension with homologous antigen evoked secondary antibody responses. The secondary 19S antibody response was rapid and transient. The secondary 7S response, which appeared to be biphasic, was of longer duration and reached peak titers about 12-13 days after antigenic restimulation. Antibody production was prolonged when spleen cells were cultured together with a feeder layer of rabbit embryo fibroblasts. Incorporation into the medium of chloramphenicol (50 [mu]/ml.) or actinomycin D (5 [mu]/ml.) inhibited the continued primary 19S antibody synthesis.

摘要： 1963年2～4月间在云南省的两个国营农场中,发生脊髓灰质炎流行。在此期间,甲县农场发现病人11例,为了预防疫情蔓延,于4月16日在该农场及邻近地区对全体10岁以下儿童,共计3,800人,给予服用Ⅰ、Ⅱ、Ⅲ型脊髓灰质炎疫苗糖丸;同时并对3名麻痹患者和20名4岁以下家庭及邻居接触者,用微量采血

摘要： 关于居民大规模服用脊髓灰质炎活疫苗后病毒学、血清学及流行病学的良好效果,已有很多报道。活疫苗的效果不仅表现于体液免疫,且可使局部肠道产生抵抗力,从而能抵制野毒株在人群中的传播,达到进一步控制此病流行的目的。为了解脊髓灰质炎及其他肠道病毒在流行季节的传播及服用活疫苗后对野毒株的排除情况,我们于1961～1962年服用脊髓灰质炎活疫苗前后对昆明市的散居健康儿童作了粪便病毒学检查。本文是报告这次试验的结果。

关键词： CELL NUCLEUS   CYTOPLASM   EXPERIMENTAL LAB STUDY   METABOLISM   NUCLEOTIDYLTRANSFERASES   POLIOVIRUS   RNA, VIRAL   TISSUE CULTURE   VIRUS CULTIVATION  

关键词： 小儿麻痹症   小儿麻痹病毒   脊髓灰质炎病毒   疫苗   菌苗  

摘要： 小儿麻痹症是由一种病毒引起的急性传染病。在自然的条件下,这种病毒只能使人发生小儿麻痹症,因此叫做人类小儿麻痹病毒。这种病毒很小,小到此头发丝还细几十万倍。用最好的光学显微镜也看不到它,只有在电子显微镜下放大几万倍,才能看到一个个圆形的病毒。小儿麻痹病毒虽然很小,但是对人的危害却很大。由于这种病毒的传染性很强,几乎每个孩子迟早都可能受它的感染。在我国,这种病多半发生在夏秋两季,得这种病的多半是六个月到七岁的小孩子。小儿麻痹病毒在自然界里,究

关键词： Poliovirus   Polio   Cerebrospinal fluid   Neutralizing antibodies   Aseptic meningitis   Poliomyelitis   Infections  

摘要： Poliovirus neutralizing antibodies of the 3 different types have been found in the cerebrospinal fluids of some patients with paralytic poliomylitis, nonparalytic poliomyelitis, and aseptic meningitis as well as in controls with nonneurologic diseases. These antibodies were demonstrable in about 1 of 4 patients and were unrelated to the disease which the patient had. This represents the minimum number of patients whose cerebrospinal fluids had antibodies, since the lowest dilution used was 1:2 and no attempt was made to con centrate the fluids for antibody determination. In some patients the ratio of the titer of group B isoagglutinins in the cerebrospinal fluid and serum was such that it ruled out the passage or seepage of serum into the cerebrospinal fluid by accidental means. The ratios of iso agglutinins in the cerebrospinal fluid to the serum were of the order of 1/256 to 1/2048, while in the same individuals the comparable ratios of poliovirus neutralizing antibodies were from 1/32 to 1/512.

关键词： Science   Humanities and Social Sciences   multidisciplinary  

摘要： SOME variants of poliovirus (E+) do not adsorb on DEAE-cellulose provided neutral 0.01–0.02 M phosphate buffer is used as a diluent; under identical conditions some other variants (E−) are almost completely detained on the ion-exchanger and can be eluted only with solutions of increased ionic strength1,2. The E character of polio-virus may be considered as a genetic property which has no complete correlation with any other marker investigated so far3–6.