关键词： Science   Humanities and Social Sciences   multidisciplinary  

关键词： Infectious Disease   Vaccine Strain   Wild Strain   Neutralize Activity   Poliovirus Type  

摘要： Antisera against vaccine strains of poliovirus types 1, 2 and 3 adsorbed with concentrated antigens of “wild” strains of the same serologic types retained their neutralizing activity only for the homologous strains. This fact allowed the serologic differentiation between vaccine and wild strains of *** differentiation of 29 type 1 strains, 4 type 2 strains and 5 type 3 strains was done with cross-adsorbed antisera.

摘要： Serum neutralizing antibody titers to poliovirus Types I, II, and III were performed on 45 young adults 10 years after immunization with trivalent oral poliovirus vaccine and compared to previous antibody titers. Eighty-four per cent of the participants had antibody titers to all three types of poliovirus in a dilution of 1:3 or greater 10 years after immunization.

关键词： 肠道病毒   核糖核酸病毒   RNA病毒   小儿麻痹病毒   脊髓灰质炎病毒   柯萨奇病毒  

摘要： 肠道病毒属于小核糖核酸病毒（Picorna viruses）科,鼻病毒及动物的小型RNA病毒亦隶属于此群。（表1）这一群病毒很小,直径15～56毫微米,呈立体对称二十面体。肠道病毒和鼻病毒在1克分子MgCl2存在下都能耐热;但不同的是前者耐酸,此点可作为鉴别特性。二者对乙醚均不敏感。人类肠道病毒为胃肠道的暂时寄居者;其存活取决于能否成功地植入所在部位的易感细胞。病毒分布于全世界,在温带地区,流行发生于温暖季节,一般呈局部性或散发性流行。同一年中各地流行的血清型不同。在家庭中,特别是幼儿较多的家庭,传播迅速。肠道病毒也引起散发病例,这些病例无疑仅是病毒在人

关键词： Infectious Disease   Serine   Chromatographic Analysis   tRNA Synthetase   Aminoacyl tRNA Synthetase  

摘要： tRNA was extracted from uninfected and poliovirus infected HEp-2 cells. The aminoacyl tRNA synthetase was obtained from rat liver. Several aminoacyl tRNAs, prepared “in vitro” were analyzed on a MAK column. Arginyl tRNA is quantitatively modified at 20 minutes of infection. After 6 hours, the incorporation of serine into seryl tRNA increases. Valyl- and leucyl tRNA remain unaltered at both periods of infection.

关键词： 脊髓灰质炎   病例   小儿麻痹   肠道病毒感染   疫苗预防   脊髓灰质炎减毒活疫苗   发病特点   新乡市  

摘要： 在伟大领袖毛主席无产阶级革命路线指引下,贯彻执行“预防为主”的方针,我市自一九六二年开展对脊髓灰质炎减毒活疫苗预防工作,取得了一定成绩,至一九七二年使年发病率平均由十万分之十左右(一九五八年年发病率高达十万分之三十八点七一)下降到十万分之三以下,一九七三年发病率下降到十万分之一点二五,现报告我市疫苗预防工作情况及分析近年来的一些发病特点。

关键词： 脊髓灰质炎病毒   白细胞移动抑制试验   抑制作用   PPD   小儿麻痹病毒   肠道病毒   基因互作   麻疹病毒   实验设备   试管  

摘要： 作者应用白细胞移动抑制试验(LMIT),比较了麻疹、腮腺炎及脊髓灰质炎等病毒在试管内对细胞免疫的影响,并讨论了麻疹对机体免疫反应的作用机理问题。实验方法:1.对34名结核病患者以纯蛋白衍化物(PPD)作为抗原,预先进行LMIT,以阳性者作为试验对象。 2.病毒:采用麻疹、腮腺炎、脊髓灰质炎及麻疹疫苗等病毒,分别进行试验。 ***:采用琼脂糖点滴法(Agarose droplet method)。本法的原理为:从人末梢血分离出白细

摘要： From 1956 to 1966 the incidence of subacute sclerosing panencephalitis (S.S.P.E.) in the northern half of the North Island of New Zealand was approximately one hundred times greater than might be expected. No case was seen before 1956, and none has been seen since 1969. The incidence of the disease was greatest in the late 1950s, then it waned and was associated with an increasing age at onset of symptoms. Mass vaccination of primary-school children with Salk vaccine was begun in 1956. The vaccine used is likely to have contained live SV40 virus. Killed measles virus is another possible contaminant. It is believed that the administration of Salk vaccine in New Zealand was related to the appearance of S.S.P.E. in the community. The idea that an unusual reaction to measles infection is the sole cause of S.S.P.E. is not consistent with the observations in New Zealand.